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ACL Tear clinical trials

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NCT ID: NCT06274008 Recruiting - Pain Clinical Trials

Exparel vs. ACB With Bupivacaine for ACL Reconstruction

Start date: October 12, 2023
Phase: Phase 1
Study type: Interventional

Opioid misuse and addiction among children and adolescents is an increasingly concerning problem. Post-surgical opioid prescriptions for commonly performed surgeries such as anterior cruciate ligament reconstruction (ACLR) increase opioid exposure in young athletes. The purpose of the current study is to determine if extended-release Bupivacaine Liposome Injectable Suspension (Exparel) is effective in decreasing at home narcotic consumption compared to standard Bupivacaine Adductor Canal Block for Anterior Cruciate Ligament (ACL) reconstruction/reconstruction for the surgical treatment of adolescents with ACL tears and concomitant pathology i.e. meniscus / cartilage injury/tear.

NCT ID: NCT06235736 Recruiting - ACL Tear Clinical Trials

Do Patients With ACL Tears Demonstrate Weakness of the Soleus Muscle?

ACL
Start date: January 17, 2024
Phase:
Study type: Observational

The goal of this prospective, cross-sectional study is to test the strength of the soleus muscle in participants who have a ACL tear confirmed by MRI. Previous studies have shown that the soleus muscle, which one of the muscles situated in the calf, decreases mechanical loading on the ACL. Therefore, we aim to test soleus muscle strength using a seated plantar flexor test. The main questions we aim to answer are: - Do patients with ACL tears demonstrate inter-limb soleus strength asymmetry (>10%) - Do patients with ACL tears have soleus muscle weakness compared with uninjured (normative) participants? - Do changes in soleus strength values correlate with patient reported outcomes and stability, as measured by the IKDC questionnaire? To achieve this the VALD force frame will be used as the testing device for plantar flexor strength testing. This device records the force generated by the movement. This will be repeated three times on each leg as part of the testing procedure. Furthermore, as part of the testing procedure participants will be required to fill out an IKDC form to assess their knee stability. Interrater reliability of the force frame will be investigated. Further data from participants without ACL tears will be used to compare results. Thus allowing us to see if people with ACL tears have a weakness in the soleus muscle.

NCT ID: NCT06156501 Recruiting - ACL Tear Clinical Trials

Psychological Factors Influencing the Patient-reported and Functional Outcome of ACL Reconstruction and Their Sex-specific Differences

Start date: August 1, 2023
Phase: N/A
Study type: Interventional

Psychological parameters among patients undergoing ACL reconstruction and their impact on the patient-reported and functional outcome of reconstruction will be prospectively evaluated

NCT ID: NCT05912777 Recruiting - ACL Tear Clinical Trials

3D Reconstruction of the Knee Based on MRI

IMAGENOU3D
Start date: September 13, 2023
Phase: N/A
Study type: Interventional

ACL tear is a pathology of the knee quite common in athletes mainly caused by a twisting movement. The diagnosis of ACL tear can be confirmed by MRI (magnetic resonance imaging). This method makes it possible to visualize the inside of the knee and to diagnose lesions associated with rupture of the ACL (in particular meniscal lesions). Obtaining a 3D model of patients' joints from a imaging is of growing interest to plan the gesture in preoperative but also to evaluate this gesture postoperatively. In orthopedic surgery, the baseline preoperative imaging is MRI. However, 3D models are generally obtained from a scanner-like imaging. In this context, obtaining a 3D model from MRI imaging would make it possible to have a model that fits into the care pathway patients, without subjecting them to irradiation and visualizing anatomical structures not visible on CT. However, the geometric precision and the reproducibility of the 3D reconstructions of joints reconstructed from an MRI remains unknown and must be evaluated to consider their clinical use.

NCT ID: NCT05582226 Recruiting - ACL Tear Clinical Trials

Augmentation of Anterior Cruciate Ligament Reconstruction Using Mesenchymal Stem Cells and Collagen Matrix Carrier

BioACL
Start date: August 16, 2022
Phase: N/A
Study type: Interventional

The goal of this observational study is to compare patient outcomes for reconstructive surgery of ACL tears. This study utilizes two randomized groups, one being the control group that receives standard ACL reconstructive surgery, while the other is the test group at will receive an injection of stem cells taken from elsewhere within the body. The main objectives are to determine the usefulness of stem cells as a cost-effective implant in reconstructive surgery and to determine if the stem cells provide more optimized healing outcomes. Participants will: - Receive ACL reconstructive surgery as normal - One-half of the participants will receive stem cells at the repair site as the test group - All participants will have 3, 6, 9, 12, 18, and 24 month followups to chart their recovery progress Thus, the outcomes of the group receiving stem cell injections will be compared directly with the outcomes of the standard ACL reconstructive care group.

NCT ID: NCT05241795 Recruiting - Clinical trials for Anterior Cruciate Ligament Injuries

Knee vs. Ankle Training on Knee Mechanics After ACLR

Start date: February 13, 2022
Phase: N/A
Study type: Interventional

This study will be conducted to investigate if there is any difference between starting rehabilitation program after ACL reconstruction with knee joint training followed by ankle joint training and starting it with ankle joint training followed by knee joint training (crossover effect) on gait parameters of the knee joint.

NCT ID: NCT04825587 Recruiting - ACL Injury Clinical Trials

The Pediatric ALL Evaluation and Trial

PALLET
Start date: April 28, 2021
Phase: N/A
Study type: Interventional

The overall aim of this multicenter RCT is to determine whether concomitant ALL reconstruction in children undergoing and ACL reconstruction will longitudinally result in a lower rate of graft failure than ACL reconstruction alone.

NCT ID: NCT04748328 Recruiting - ACL Tear Clinical Trials

Comparison Effectiveness Analysis Between ACL Reconstruction and Rehabilitation in Peripheral and Main Capital in Indonesia

Cetjap-Asin
Start date: March 1, 2021
Phase:
Study type: Observational [Patient Registry]

The study was a prospective observational study analysis of cases having complete ACL tear. Study conduct between February 2021 to December 2023. All the patients attending the emergency or Out Patient Department (OPD) of those hospitals with knee injuries were evaluated for an ACL tear. Patients who meet inclusion criteria and give consent for participation in the study will observe for two years. Patient in Arifin Achmad Hospital Pekanbaru will follow rehabilitation treatment and optional delayed reconstruction after 12 weeks, while patient in Gatot Subroto Army Hospital Jakarta will performed early reconstruction treatment. After taking informed consent, all subjects were provided a self-administered patient questionnaire containing International Knee Documentation Committee (IKDC) score, ACL-RSI, Lysholm, and Tegner Activity Level (TAL) scores. These questionnaires will be measured at 0, 12, 24, 48, and 96 weeks. Besides that, all subjects were provided SF12 for measuring utility value by converting to SF6D. Clinical value of the Lachman test, pivot shift test will be performed. One independent orthopedic surgeon will keep all records and evaluate the results. All costs for the treatment will be accounted for.

NCT ID: NCT04732585 Recruiting - Clinical trials for Patellofemoral Pain Syndrome

Kinematic Assessment of Human Peripheral Joints by Dynamic CT

Karma-4D
Start date: June 1, 2020
Phase: N/A
Study type: Interventional

Aim of the research project: The entire research project aims to investigate human peripheral joints (knee, foot & ankle, elbow, wrist & hand) by dynamic 4D radiographic imaging acquisition during real-time motion. Aim of the specific study on Patellofemoral pain syndrome (PFPS) patients: This study aims to investigate kinematics and motion changes pre and post physiotherapy intervention in patients with patellofemoral pain syndrome (PFPS) and compare them with a healthy control group. Aim of the specific study on patients undergoing ACL reconstruction: This study aims to investigate kinematics and motion changes pre and post-surgical intervention in patients with ACL injury that require surgical reconstruction and compare them with a healthy control group.

NCT ID: NCT04682392 Recruiting - ACL Tear Clinical Trials

ACL Bone Health and Loading Study

ACLBONE
Start date: February 17, 2021
Phase: N/A
Study type: Interventional

The purpose of this study is to look at the effects of bone density on lower extremity loading mechanics using Blood Flow Restriction (BFR) to provide the control group for bone health. Hypothesis: The BFR group will have decreased bone mineral loss and improved functional performance compared to control group.