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Soft-tissue Quadriceps Autograft ACL-reconstruction in the Skeletally-immature vs. Hamstrings — SQuASH  

ACL - Anterior Cruciate Ligament Rupture Clinical Trial

Official title:
Soft-tissue Quadriceps Autograft ACL-reconstruction in the Skeletally-immature vs. Hamstrings (SQuASH): A Multi-Centre Randomized Controlled Trial

Clinical Trial Summary

To date, the use of the quadriceps tendon as an autograft option in primary paediatric Anterior Cruciate Ligament (ACL) reconstruction has not been well studied. The 2018 International Olympic Committee (IOC) Consensus Statement now outlines the quadriceps tendon as a possible autograft option. However, no Randomised Control Trial (RCT) has examined the efficacy of the quadriceps tendon autograft in primary paediatric ACL reconstruction compared to the historical "gold-standard" soft-tissue hamstring autograft in this population. In light of its evidence for favourable outcomes in the adult population, and the (albeit limited) evidence showing safety and promise in the paediatric population, clinical equipoise exists for assessing its impact on outcomes in paediatric patients at the index surgery. This trial aims to demonstrate feasibility of a global RCT that will evaluate the efficacy of soft-tissue quadriceps versus hamstring autograft tendons on re-operation, return to sport, and knee function among paediatric patients undergoing primary ACL reconstruction.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

  • ACL - Anterior Cruciate Ligament Rupture
  • Rupture
Clinical Trial Details
NCT number NCT03896464
Study type Interventional
Source McMaster University
Contact Darren de SA, MD, FRCSC
Phone 9059232126
Email darren.desa@medportal.ca
Status Recruiting
Phase N/A
Start date January 1, 2020
Completion date January 1, 2026
View Details
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