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Acetaminophen clinical trials

View clinical trials related to Acetaminophen.

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NCT ID: NCT04459117 Recruiting - Extreme Prematurity Clinical Trials

Prophylactic Treatment of the Ductus Arteriosus in Preterm Infants by Acetaminophen

TREOCAPA
Start date: October 29, 2020
Phase: Phase 2/Phase 3
Study type: Interventional

TREOCAPA is a Phase II/III European Multicentre study concerning the prophylactic treatment by Acetaminophen of extremely preterm infant during the first five days after birth. The Phase II is a dose finding phase in order to assess the minimum effective dose regimen of acetaminophen for the closure of PDA for neonates with a gestational age less than 27 weeks This part of the study will be conducted in 11 NICUs, in 4 countries (France, UK, Finland and Denmark). The Phase III is The phase III is a randomized, multicenter, double-blind, placebo-controlled superiority trial, two arms in a 1:1 ratio, evaluating an increasing of 10% of the percentage of survival without severe morbidity at 36 weeks of post menstrual age. In the intervention arm, 20 mg/kg followed by 7.5 mg/kg quarter in die (QID) will be administered to the 27-28 weeks gestational age group (dosage confirmed through PK/PD data analysis from the previous Finnian study) and the dosage selected after the conclusion of the Phase II will be administered to the 23-26 weeks gestational age group. A group sequential design, with a total of 3 analyses (2 interim analyses and a final) and the O'Brien-Fleming alpha spending function is chosen for the trial. At the same time, a Bayesian sequential analysis is planned for safety endpoints

NCT ID: NCT04290208 Recruiting - Postoperative Pain Clinical Trials

A Comparison of IV Versus PO Acetaminophen Postoperatively for Opioid Consumption After Cesarean Section

Start date: August 22, 2019
Phase: Phase 4
Study type: Interventional

This randomized controlled study will compare narcotic consumption between two groups: patients that receive a perioperative dose of IV acetaminophen versus patients that receive a perioperative dose of oral liquid acetaminophen for scheduled cesarean section.

NCT ID: NCT04175509 Recruiting - Postoperative Pain Clinical Trials

Improving Post-Operative Pain and Recovery in Gynecologic Surgery

Start date: December 23, 2019
Phase: Phase 4
Study type: Interventional

This is a clinical investigation to determine the efficacy of rectal versus intravenous acetaminophen in patients undergoing a minimally invasive hysterectomy. All women will receive acetaminophen either rectally or intravenously immediately postoperative, prior to extubation. Patient's will be randomly assigned to either the rectal acetaminophen or the intravenous acetaminophen group. Patient outcomes will be measured through a Numeric Rating Scale (NRS) from 0-10 for pain scores, and total opioid consumption measured in morphine milligram equivalent (MME) for the first 24 hours following surgery, or upon discharge, whichever comes first.

NCT ID: NCT03763084 Recruiting - Delirium in Old Age Clinical Trials

Impact of Acetaminophen on Postoperative Delirium Elderly Patients After Non-cardiac Surgery

Start date: February 15, 2019
Phase: Early Phase 1
Study type: Interventional

To investigate the impact of acetaminophen analgesia on the frequency of postoperative delirium and 28 days mortality in elderly patients after noncardiac surgery.

NCT ID: NCT03295214 Recruiting - Acetaminophen Clinical Trials

Acetaminophen Given Per Os and Intravenous in Sinus Surgery

Start date: March 28, 2018
Phase: Phase 3
Study type: Interventional

The primary objective of this study is to investigate the Visual Analog Score (VAS) for pain within the post-operative setting and determine if there is a statistically significant difference between the VAS for PO or IV acetaminophen. It is expected that in doing so the investigators can produce the maximal amount of pain relief after surgery while making conscientious monetary decisions.

NCT ID: NCT02839876 Completed - Osteoarthritis Clinical Trials

Intravenous Versus Oral Acetaminophen in Primary Total Hip Arthroplasty

Start date: March 14, 2017
Phase: Phase 4
Study type: Interventional

The purpose of this study is to determine if intravenous acetaminophen is superior to oral acetaminophen when used as part of a multimodal pathway for primary total hip arthroplasty.