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Abortion, Spontaneous clinical trials

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NCT ID: NCT06452719 Not yet recruiting - Miscarriage Clinical Trials

Letrozole and Misoprostol for Early Pregnancy Loss Management: A Prospective Pilot Cohort Study

LeMi
Start date: July 15, 2024
Phase: Phase 2
Study type: Interventional

A pilot cohort study to preliminarily investigate the efficacy of pretreatment with letrozole 10 mg daily for three consecutive days followed by treatment with misoprostol 800 mcg vaginally for medical management of early pregnancy loss in a US population. Patients will be followed to assess efficacy of this treatment regimen, as well as additional interventions needed, side effects, adverse events, and patient acceptability.

NCT ID: NCT06408181 Recruiting - Pre-Eclampsia Clinical Trials

APPLE: Aspirin to Prevent Pregnancy Loss and Preeclampsia

APPLE
Start date: June 12, 2024
Phase: Phase 3
Study type: Interventional

The goal of this clinical trial is to investigate the effects of early initiation of double low-dose aspirin in pregnant women. The main questions it aims to answer are: Does this dose and timing of aspirin reduce the risk of pre-eclampsia compared to standard recommendations? Does this dose and timing of aspirin reduce the risk of pregnancy loss compared to standard recommendations? Participants will begin taking at no later than 6 weeks 6 days gestational age, either 162mg of aspirin through delivery or placebo until 12 weeks and then 81mg of aspirin through delivery.

NCT ID: NCT06393426 Completed - Infertility Clinical Trials

The Constitution and Efficacy of Chinese Medicine of Infertility Male, Female, and Pregnant Female

Start date: January 1, 2023
Phase:
Study type: Observational

The project aims to conduct a retrospective study to assess the impact of Traditional Chinese Medicine (TCM) on improving pregnancy rates and preventing miscarriages. It will include patients with infertility issues or a history of miscarriage. The study will analyze demographic and physiological data, TCM constitution, basal body temperature, reproductive history for females, and semen analysis for males, to determine the effectiveness of TCM care in enhancing fertility outcomes.

NCT ID: NCT06385444 Not yet recruiting - Clinical trials for Psychological Stress

IVF Failure and Pregnancy Loss on Couples' Psychological Stress

Start date: May 1, 2024
Phase:
Study type: Observational

The goal of this observational study is to learn about The purpose of this study was to compare the psychological differences between couples after IVF transplant failure and IVF pregnancy loss, including the differences in anxiety, depression, stress and post-traumatic stress between women and their spouses. The main question it aims to answer is: What are the psychological effects of IVF implantation failure and IVF pregnancy loss on women and the psychological differences between couples? Participants already taking IVF as part of their regular medical care will answer online survey questions about their joint pain for 1 years.

NCT ID: NCT06384144 Recruiting - Clinical trials for Miscarriage in First Trimester

Machine Learning Miscarriage Management Clinical Decision Support Tool Study

MLMM
Start date: January 1, 2023
Phase:
Study type: Observational

Machine learning used to develop an algorithm to determine chance of success with expectant or medical management for an individual patient. Taking into account the following objective measures: - Demographics: Maternal Age, Parity - History: Previous CS, Previous SMM/MVA, Previous Myomectomy - Gestation by LMP - Presenting symptoms: Bleeding score, Pain score - USS Measurements: CRL, GS, RPOC 3 dimensions, Vascularity - Discrepancy between gestation by CRL and LMP Audit to collate 1000 cases and identify features contributing to an algorithm that can predict outcome of miscarriage management for individualized case management.

NCT ID: NCT06356792 Recruiting - Clinical trials for Recurrent Miscarriage

Obstetrics , Prenatal Outcomes in Recurrent Miscarriage

OBPORPL
Start date: April 21, 2024
Phase:
Study type: Observational

The effect of recurrent miscarriage on the outcome of the current pregnancy and if there's a relation between it and adverse out come

NCT ID: NCT06309927 Not yet recruiting - Clinical trials for Intrauterine Adhesion

Operative Hysteroscopy Versus Suction Curettage for Surgical Termination of Early Pregnancy Loss (Miscarriage)

Start date: April 2024
Phase: N/A
Study type: Interventional

Non-blinded prospective randomized study. 100 women diagnosed with early pregnancy loss up to 10 gestational weeks who opted for surgical management (after being offered the options of conservative management and medical treatment) will be recruited. Qualifying patients will sign an informed consent form and will be randomly assigned to the two arms of the study: 1. Surgical uterine evacuation by the traditional ultrasound-guided suction curettage (control group) 2. Surgical uterine evacuation by operative hysteroscopy using a tissue removal device (study group). The surgical procedure will be determined randomly by computer generated allocation. All surgical procedures will be performed under general anesthesia in an outpatient surgical suite. The operative time, operative blood loss and intraoperative complications will be recorded by the research team. Following the surgical procedure, the patients will be monitored and discharged home as per our department's day-surgery protocol. Immediate post-operative complications will be recorded until discharge. One week after the procedure, a telephone interview will be conducted to assess any procedure-related complications. A diagnostic hysteroscopy without anesthesia will be scheduled 6 weeks postoperatively to assess for retained products of conception and for intrauterine adhesions. The diagnostic hysteroscopy will be performed by a practitioner who will be blinded to the type of surgery performed. 6 months after the procedure, a telephone questionnaire will be conducted to assess for subsequent pregnancies.

NCT ID: NCT06295939 Active, not recruiting - Grief Clinical Trials

Effect of Social Support Program on Grief of Pregnancy Loss in Sunpasitthiprasong Hospital

Start date: April 29, 2022
Phase: N/A
Study type: Interventional

Research Question: Does participation in a social support program have an impact on the Perinatal Grief Scale of women who experience pregnancy loss through abortion? Research hypothesis 1. The grief scores from pregnancy loss among women who had to terminate their pregnancies in the group receiving social support program were lower than those in the group receiving standard nursing care. 2. The grief scores from pregnancy loss among women who had to terminate their pregnancies after receiving the social support program were lower than those before receiving the social support program. Primary Objectives: To study the grief and sorrow resulting from the loss of a fetus due to pregnancy termination in women who have undergone social support programs, in comparison to those who have received regular nursing care. Secondary Objectives: 1. To investigate the grief and sorrow resulting from the loss of a fetus due to pregnancy termination after receiving social support programs compared to before receiving such programs. 2. To examine the grief and sorrow following pregnancy termination before returning home and one month after miscarriage. 3. To explore other outcomes of pregnancy termination, such as complete abortion, uterine curettage, and post-miscarriage complications.

NCT ID: NCT06262373 Completed - Clinical trials for Miscarriage in First Trimester

Angular Pregnancy - Ultrasound Definition and Correlation With Clinical Outcomes

Start date: October 1, 2017
Phase:
Study type: Observational

The aim of this study is to establish clinically meaningful ultrasound-based diagnostic criteria for AP. To this end, the investigators will prospectively collect clinical and ultrasound data from early intrauterine pregnancies and correlate this data with pregnancy outcomes (particularly with risk of miscarriage), to establish whether there are any diagnostic criteria that can be used to make the diagnosis, facilitate increased surveillance of at risk pregnancies and reassure those with normally located pregnancies. The collected data will be used to correlate incidence of angular pregnancy and clinical variables such as maternal age, uterine fibroids, assisted conception, multiple pregnancy, ethnicity, previous uterine and adnexal surgery.

NCT ID: NCT06261203 Recruiting - Pre-Eclampsia Clinical Trials

Low Dose Aspirin for Prevention of Early Pregnancy Loss

Start date: July 1, 2023
Phase: N/A
Study type: Interventional

Preeclampsia is a pregnancy-specific, multisystem disorder affecting 3% to 8% of pregnancies and remains a significant cause of maternal and neonatal morbidity and mortality worldwide. The World Health Organization estimates that approximately 76,000 maternal deaths annually are attributed to preeclampsia, accounting for 16% of global maternal mortality, with the majority occurring in low- and middle-income countries