Intravenous Administration of Magnesium Sulfate in Hysterectomy Cases

Status Completed

Clinical Trial Summary

In our study, it was aimed to show the contribution of intraoperative intravenous magnesium sulfate administration to peroperative opioid consumption and postoperative analgesia.

Clinical Trial Description

Postsurgical pain is one of the most important issues that could impress on postoperative peace and comfort. Abdominal hysterectomy associated with intense inflammatory response, resulting in moderate to severe postoperative pain perception The major goal in postoperative pain management is to minimize the dose of medications and lessen side effects, while still providing adequate analgesia. Postoperative pain relief leads to earlier mobilization, shortened hospital staying, reduced hospital costs, and increased patient satisfaction Narcotics are the most common analgesics which are used after the surgeries. But anesthetists are always looking for replaceable methods with fewer side effects and cost . It seems adjuvant analgesics are those desirable replacements. Nowadays there have been many debates on the role of adjuvant analgesics on postoperative pain relief. One way to use adjuvant analgesics is preventive method Preventive analgesia is a method initiated before anesthetic procedure in order to reduce the physiological consequences of nociceptive stimulation and medical adverse effects and has been defined as an antinociceptive treatment that prevents establishment of altered central processing ofafferent input from injuries. One of the intravenous adjuvant that has been shown potential in preventive analgesia is magnesium sulfate that could be administered with multiple routes or methods Mg has been used for many years in anesthesia and cardiology as an anticonvulsant or antiarrhythmic drug. The mechanism of the analgesic effect of Mg is not clear but inter- ference with calcium channels and N-methyl-D-aspartate (NMDA) receptor seem to play an important role. It seems that analgesic mechanism of NMDA-antagonists is made by preventing nociceptive central sensitization. Another suggesting mechanism is the role of it on reduction of catecholamine release with sympathetic stimulation, thereby decreasing peripheral nociception or the stress response to the surgery. Data illustrate that the NMDA receptor antagonists "like Mg sulfate" have an effect on pain threshold and could prevent pain perception even with low doses (preventive doses) In our study, investigators aimed to determine the contribution of magnesium sulfate to postoperative analgesia in abdominal hysterectomy by considering its mechanism of action. The patients were divided into two groups as magnesium sulfate administered and non-administered The magnesium group received a bolus of 20 mg/kg of magnesium sulfate in 100 mL of saline for 15 minutes before induction, followed by a continuous infusion of 20 mg/kg/hr until the skin was closed. The same volume of isotonic saline for the control group was administered as indicated in the magnesium group. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05644873
Study type	Interventional
Source	Ondokuz Mayis University
Contact
Status	Completed
Phase	N/A
Start date	November 15, 2023
Completion date	April 30, 2024

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04577430` - Effects of Dexmedetomidine on Cardiac Electrophysiology in Patients Under General Anesthesia During Perioperative Period	N/A
Completed	`NCT03708692` - Menstrual Cycle Phases on Recovery and Cognitive Function
Recruiting	`NCT03422315` - Population Pharmacokinetics and Clinical Individual Dosage Regimen of Propofoll Injection	N/A
Completed	`NCT02771067` - The Utility of Pulse Pressure Variation to Predict the Fluid Responsiveness During Pneumoperitoneum and Reverse-Trendelenburg Position	N/A
Completed	`NCT05063461` - Evaluation of the Analgesia Nociception Index With Varying Remifentanil Concentrations Under Sevoflurane	N/A
Completed	`NCT03294226` - Comparison of AuraGain With I-gel for Pediatric Patients	N/A
Not yet recruiting	`NCT03643029` - The Accuracy of the Performance and Placement Test for Predicting Supraglottic Airway Device (SAD) Position in the Hypopharynx as Confirmed With Video Laryngoscopy	N/A
Completed	`NCT01945411` - Assessment of Facial Measurements, the Length of Mouth Corner-mandible Angle and Incisors-mandible Angle, for Determining the Proper Sizes of Oropharyngeal Airway	N/A
Not yet recruiting	`NCT01678066` - A Prospective Study to Bilaterally Compare a Non-Invasive Cardiac Output Monitor	N/A
Completed	`NCT01705743` - Minimum Alveolar Concentration of Sevoflurane With Nitrous Oxide Inducing Isoelectric EEG	Phase 4
Completed	`NCT00972491` - The Optimal Time to Put Laryngeal Mask Airway in the Mouth Under General Anesthesia	N/A
Completed	`NCT00741507` - Unhealthy Alcohol Drinking and Anesthetic Requirement in Women	N/A
Completed	`NCT01096212` - Efficacy and Safety of Sevofran in Patients Scheduled for Elective Surgery Under General Anesthesia	Phase 4
Completed	`NCT00599066` - Intraoperative M-Entropy Measurements	N/A
Completed	`NCT00532402` - Continuous and Discontinuous Determination of Propofol Concentration in Breathing Gas	N/A
Completed	`NCT00468494` - Can Blood Glucose Levels During the Perioperative Period Identify a Population at Risk for Hyperglycemia?	N/A
Recruiting	`NCT00492453` - Spinal Versus General Anesthesia for Laparoscopic Cholecystectomy	N/A
Recruiting	`NCT03745079` - Correlation Between Core Temperature and Skin Temperature Measured by 3M SpotOn
Completed	`NCT04094376` - Comparison of Morning Operation and Evening Operation on Postoperative Sleep Quality and Pain Under General Anesthesia	N/A
Enrolling by invitation	`NCT03672734` - Volume and pH of Gastric Contents in Patients Undergoing Gynecologic Laparoscopic Surgery During Emergence From General Anesthesia