Intravenous Ascorbic Acid Administration in Hysterectomy

Abdominal Hysterectomy Clinical Trial

Official title:

Effect of Ascorbic Acid Administration on Intraoperative Blood Loss and Wound Healing in Total Abdominal Hysterectomy

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03965637
• Other study ID #: 17912
• Status: Completed
• Phase: Phase 3
• Start date: August 23, 2019
• Est. completion date: January 30, 2020

Study information

• Verified date: April 2020
• Source: Shahid Beheshti University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

vitamin C or ascorbic acid has known role in tissue repair. due to it's properties(water_soluble), vitamin c is not stored in the body and when depleted, the bleeding tendency will increase due to dysfunctional connective tissues production in vessel wall and it has some important functions in platelets.

Description:

In this randomized clinical trial, 1000 mg vitamin C will administrate intravenously a day before surgery and during surgery in patients who undergo abdominal hysterectomy.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 80
• Est. completion date: January 30, 2020
• Est. primary completion date: January 30, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• To be 18 years and older

• No smoking

• No history of bleeding disorder

• No history of favism

• No history of uterus, ovary, cervical cancer

Exclusion Criteria:

• Need to injection of vasopressor drugs

• Surgeon disagreement

Related Conditions & MeSH terms

• Abdominal Hysterectomy

Intervention

Drug:
• vitamin C
water-soluble vitamin C injection contain of 1000 mg vitamin C that given via intravenous injection

Locations

Country	Name	City	State
Iran, Islamic Republic of	Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences	Tehran

Sponsors (1)

Lead Sponsor	Collaborator
Shahid Beheshti University

Country where clinical trial is conducted

Iran, Islamic Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	volume of hemorrhage	volume of hemorrhage during surgery	During surgery
Secondary	Hemoglobin value	Hemoglobin value after surgery	6 and 24 hours after surgery
Secondary	wound healing	complications after surgery	during 2 weeks post surgery
Secondary	duration of stay in hospital	Length of stay in hospital	up to 2 weeks post surgery
Secondary	Infection	Developing infection up to 2 weeks	up to 2 weeks post surgery