The Effects of Morphine on Desflurane Consumption and Recovery Time

Abdominal Hysterectomy (& Wertheim) Clinical Trial

Official title:

Comparison of Two Different Doses of Intravenous Morphine on Desflurane Consumption and Recovery Time in Patients Undergoing Total Abdominal Hysterectomy

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02362022
• Other study ID #: 14.09.2007/88-4
• Status: Completed
• Phase: Phase 4
• First received: February 4, 2015
• Last updated: December 2, 2015
• Start date: September 2007
• Est. completion date: December 2007

Study information

• Verified date: June 2015
• Source: Baskent University
• Contact: n/a
• Is FDA regulated: No
• Health authority: Unspecified
• Study type: Interventional

Clinical Trial Summary

Combination of volatile and opioid agents are used to achieve unconsciousness, haemodynamic stability and analgesia for surgical prosedures. This prospective, randomized, double-blind, controlled study evaluates the effects of two different doses of morphine sulphate (0.1 mg/kg and 0.2 mg/kg), on desflurane consumption, recovery characteristics, postoperative analgesic requirements and side effects during total abdominal hysterectomy.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 90
• Est. completion date: December 2007
• Est. primary completion date: December 2007
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 40 Years to 60 Years

Eligibility

Inclusion Criteria:

• undergoing total abdominal hysterectomy with general anaesthesia

Exclusion Criteria:

• renal dysfunction (cre>1.2), liver failure, cardiovascular, psychiatric, allergic and metabolic disorders

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Caregiver, Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Abdominal Hysterectomy (& Wertheim)

Intervention

Drug:
• Morphine
Group Saline (Group S): Received i.v saline 0.9 % in 10 ml volume (n=30) Group Morphine 1 (Group M1): Received i.v morphine 0.1 mg kg-1 in 10 ml volume (n=30) Group Morphine 2 (Group M2): Received i.v morphine 0.2 mg kg-1 in 10 ml volume (n=30)

Locations

Country	Name	City	State
Turkey	Baskent University School of Medicine Adana Teaching and Research Hospital	Adana

Sponsors (1)

Lead Sponsor	Collaborator
Baskent University

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	postoperative desflurane consumption		postoperative first hour	Yes
Primary	sedation scores for OASS scale		postoperative first hour	Yes