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Clinical Trial Summary

Periprocedural treatment with high-dose statins is known to have cardioprotective and pleiotropic effects, such as anti-thrombotic and anti-inflammatory actions.

-Objective: to determine whether preoperative rosuvastatin loading is independently associated with reduced myocardial ischemia and clinical outcomes in patients with stable angina undergoing isolated off-pump coronary bypass (OPCAB) in patients with acute coronary syndrome.

Study design

- Prospective, double-blinded, single-center study of each 117 subjects enrolled

- Subjects with acute coronary syndrome who meet all inclusion and exclusion criteria will be enrolled preoperatively.

- Eligible subjects will be randomized 1:1 to A) High-dose rosuvastatin (n=117) vs. B) Placebo (n=117).

- The amount of preoperative administration of high-dose rosuvastatin will be 60mg of a total

- All subjects will undergo OPCAB procedure. - The primary and secondary endpoints will be compared at 30 days and 2 years postoperatively between two groups


Clinical Trial Description

n/a


Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Supportive Care


Related Conditions & MeSH terms


NCT number NCT01971606
Study type Interventional
Source Yonsei University
Contact
Status Completed
Phase Phase 4
Start date October 2007
Completion date March 2013