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2019 Novel Coronavirus Infection clinical trials

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NCT ID: NCT04778059 Not yet recruiting - Clinical trials for Respiratory Distress Syndrome, Adult

Safety and Efficacy of USB002 for Respiratory Distress Due to COVID-19

Start date: April 2021
Phase: Phase 2
Study type: Interventional

This trial will study the use of USB002 given as an intravenous infusion in patients with respiratory distress due to infection with COVID-19.

NCT ID: NCT04470583 Recruiting - COVID-19 Clinical Trials

Evaluating Clinical Parameters of COVID-19 in Pregnancy

Start date: October 9, 2020
Study type: Observational

Coronavirus infection, also known as COVID-19, has become a global pandemic with over 3 million cases and 250,000 deaths worldwide. Coronaviruses (CoV) belong to a family of viruses that predominately infect mammals and birds, affecting their lungs, intestinal tract, liver and nervous systems. Prior to the discovery of the current novel coronavirus strain (SARS-CoV-2), there were six different strains that are known to infect humans, which includes the virus that caused the severe acute respiratory syndrome (SARS) pandemic in 2002. In humans, the majority of severe illness from SARs and COVID-19 is due to inflammation of the lungs and pneumonia. Pregnancy poses a significantly increased risk of viral pneumonia and during SARS more pregnant women required intensive care and breathing support, and the proportion of deaths was higher when compared to non-pregnant adults. Furthermore, kidney failure and development of abnormal blood clotting disorders, which occurs during severe infection, is more common in pregnancy and the associated changes in blood vessels extend to the placentas of infected pregnant women, thus potentially affecting the fetus. This makes pregnant women affected by the virus at high risk of developing severe complications. Fortunately, there have been a number of biomarkers identified that are associated with illness severity. These include, specialised white blood cells, blood clotting cells and constituents, as well as other measures of heart and kidney function. We propose that these biomarkers are important correlates of clinical disease severity and prognosis in pregnant and postnatal women. This knowledge has the potential to help clinicians during this pandemic to better manage and care for their patients.

NCT ID: NCT04459351 Recruiting - COVID-19 Clinical Trials

PHenotyping patiENts Admitted to Hospital With cOvid-19 Infection and idenTifYing Prognostic markErs

Start date: June 19, 2020
Study type: Observational

PHENOTYPE is an investigator-led, observational cohort study which aims to explore the long-term outcomes of patients with COVID-19 infection and to identify potential risk factors and biomarkers that can prognosticate disease severity and trajectory.

NCT ID: NCT04320238 Recruiting - Clinical trials for 2019 Novel Coronavirus Infection

Experimental Trial of rhIFN╬▒ Nasal Drops to Prevent 2019-nCOV in Medical Staff

Start date: January 21, 2020
Phase: Phase 3
Study type: Interventional

The investigators plan to carry out an experimental study on the preventive effect of recombinant human interferon alpha nasal drops on the infection of 2019 new coronavirus in medical staff.