Clinical Trials Logo

Virologic Failure clinical trials

View clinical trials related to Virologic Failure.

Filter by:
  • None
  • Page 1

NCT ID: NCT05373758 Recruiting - HIV Infections Clinical Trials

A Randomized Clinical Trial to Evaluate Solutions for the Management of Virologic Failure on TLD in Sub-Saharan Africa

RESOLVE
Start date: February 7, 2024
Phase: N/A
Study type: Interventional

The RESOLVE trial is an open, parallel arm, randomized clinical trial which aims to determine the optimal strategy for management of virologic failure on first-line antiretroviral therapy (ART) with tenofovir, lamivudine, and dolutegravir (TLD) in sub-Saharan Africa. The primary outcome of interest will be viral suppression to <50 copies/mL at 48 weeks using the FDA snapshot definition. The study will be conducted in Uganda and South Africa.

NCT ID: NCT04612452 Completed - Hiv Clinical Trials

The DTG-SWITCH Study: Longitudinal Analysis of Virologic Failure and Drug Resistance at and After Switching to Dolutegravir-based First-line ART

DTG-SWITCH
Start date: November 5, 2019
Phase:
Study type: Observational

This is a prospective observational cohort study of 2820 patients on first-line ART switching to a DTG-based first-line regimen, according to the standard of care. The study is conducted in Malawi and Zambia, in ART programs that participate in the IeDEA collaboration. Sequencing will be done on blood samples of patients with a viral load above 400 copies/mL to identify mutations.