Ventilator Settings on Patients With Acute Brain Injury

Status Completed

Clinical Trial Summary

The present study is an explorative analysis of the relationship between cerebral blood perfusion and oxygenation and lung mechanical variables at different ventilator settings. It is a safety study excluding patients with severe lung injury or brain edema.

Clinical Trial Description

The primary goal is to carry out baseline measurements to enable conclusions concerning the safety of lung protective ventilator settings before extending the study to patients with more severe brain and/or lung injury in the future. The primary objective is to investigate if lung protective ventilator settings (higher Positive end-expiratory pressure and lower tidal volume) as compared with conventional settings. 1. increase intracranial pressure 2. diminish cerebral vasoreactive autoregulation as assessed by pressure reactivity index, ie pressure reactivity index will turn positive, which means that it will change the state from intact to impaired autoregulation. The secondary objective is an exploratory analysis of the relationship between ventilator settings and other well defined respiratory, cerebral, and cardiovascular variables, including transpulmonary pressure. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03278769
Study type	Interventional
Source	University Hospital of North Norway
Contact
Status	Completed
Phase	N/A
Start date	June 1, 2019
Completion date	January 1, 2022

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