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Additive Anti-inflammatory Action for Aortopathy & Arteriopathy (Ulinastatin) II

Type A Aortic Dissection Clinical Trial

Official title:
Effects of Ulinastatin on Inflammatory Response for Acute Aortic Syndrome Patients

Clinical Trial Summary

Acute Aortic Syndrome (AAS) is a common feature of acute aortic wall events, including aortic dissection, intramural hematoma, aortic ulceration and aortic trauma, and occurs in up to 35 cases per 100,000 cases per year between the ages of 65 and 75 years. Ulinastatin has antiinflammatory activity and suppresses the infiltration of neutrophils and the release of elastase and chemical mediators from neutrophils. Recent studies have shown that ulinastatin may be cytoprotective against ischemia-reperfusion injury in the liver, kidney, heart, and lung. The authors aim to examine the association between decreased release of inflammatory response to urinary trypsin inhibitor treatment and decreased myocardial and lung injury after acute aortic syndrome surgery.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04711889
Study type Interventional
Source Nanjing Medical University
Contact
Status Completed
Phase N/A
Start date January 1, 2021
Completion date June 30, 2022
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