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Type A Aortic Dissection clinical trials

View clinical trials related to Type A Aortic Dissection.

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NCT ID: NCT06199401 Not yet recruiting - Clinical trials for Complication of Surgical Procedure

Safety and Efficacy of XJ-Procedure in Patients With Acute Type A Aortic Dissection Surgery

ADVANCED-XJ-?
Start date: March 1, 2024
Phase: N/A
Study type: Interventional

This is a national, multicenter, open-label, randomized, controlled, endpoint-blinded clinical trial of patients diagnosed with ATAAD and undergoing "Sun's procedure" coordinated by the First Affiliated Hospital of Xi'an Jiaotong University, China. Per the protocol, "Sun's procedure" combined with "XJ-Procedure" in the anastomosis of the aortic root and Sun's procedure combined with regular suturing methods of the aortic root will be compared.

NCT ID: NCT05927090 Enrolling by invitation - Clinical trials for Aortic Valve Insufficiency

Outcomes of Type A Aortic Dissection Repair

STAAD
Start date: January 1, 2005
Phase:
Study type: Observational [Patient Registry]

Type A aortic dissection (TAAD) is a potentially life-threatening pathology associated with significant risk of mortality and morbidity. In acute forms of type A aortic dissection (TAAD) mortality is 50% by 24 h and 50% of patients die before reaching a specialist center. Rapid diagnosis and subsequent prompt surgical repair remain the primary goal for these patients. In the last decade it has been observed that improvements in diagnostic techniques, initial management and increased clinical awareness have contributed to a substantial increase in the number of patients benefiting from a prompt diagnosis and undergoing surgery.However, survival after surgical repair has not yet reached optimal follow-ups and is burdened by high in-hospital mortality(16-18%)

NCT ID: NCT05751200 Completed - Clinical trials for Type A Aortic Dissection

Safety and Efficacy of Aortic Root Reinforcement Combined With Vascular Grafts Eversion and built-in Procedure (XJ-procedure) in Patients With Acute Type A Aortic Dissection (ADVANCED-XJ )

Start date: March 1, 2023
Phase:
Study type: Observational

This is a retrospective study based on the data available in our hospital database for ATAAD patients from January 2020 to December 2021. These patients were divided into two groups according to the surgical procedures of aortic root. This study compared baseline data, perioperative and short-term follow-up results between the two groups to evaluate the efficacy and safety of XJ-procedure in ATAAD.

NCT ID: NCT05346497 Completed - Clinical trials for Type A Aortic Dissection

Surgical Management of the Aortic Root and Long-term Outcomes For Acute Type A Aortic Dissection

Start date: January 1, 2005
Phase:
Study type: Observational

The investigators focus on the patients who underwent aortic root surgery for acute type A aortic dissection between 2005.01-2021.11. The patients are divided into 3 groups according to the different aortic root surgical methods(Bentall,David and root reconstruction). Clinical data including age, gender, comorbidities, surgical informations and perioperative informations will be collected. All patients will receive follow-ups in hospital or by telephone. All the informations will be analyzed by SPSS to show the difference of both perioperative and long-term results among different surgical strategies.

NCT ID: NCT04831073 Active, not recruiting - Clinical trials for Type A Aortic Dissection

European Registry of Type A Aortic Dissection

ERTAAD
Start date: February 28, 2023
Phase:
Study type: Observational

Acute Stanford type A aortic dissection (TAAD) is a life-threatening condition. Surgery is usually performed as a salvage procedure and is associated with significant postoperative early mortality and morbidity. Understanding the patient's conditions and treatment strategies which are associated with these adverse events is essential for an appropriate management of acute TAAD.

NCT ID: NCT04711889 Completed - Clinical trials for Acute Aortic Syndrome

Additive Anti-inflammatory Action for Aortopathy & Arteriopathy (Ulinastatin) II

Start date: January 1, 2021
Phase: N/A
Study type: Interventional

Acute Aortic Syndrome (AAS) is a common feature of acute aortic wall events, including aortic dissection, intramural hematoma, aortic ulceration and aortic trauma, and occurs in up to 35 cases per 100,000 cases per year between the ages of 65 and 75 years. Ulinastatin has antiinflammatory activity and suppresses the infiltration of neutrophils and the release of elastase and chemical mediators from neutrophils. Recent studies have shown that ulinastatin may be cytoprotective against ischemia-reperfusion injury in the liver, kidney, heart, and lung. The authors aim to examine the association between decreased release of inflammatory response to urinary trypsin inhibitor treatment and decreased myocardial and lung injury after acute aortic syndrome surgery.

NCT ID: NCT04032366 Recruiting - Clinical trials for Type A Aortic Dissection

iNO as Salvage Treatment of Hypoxemia After TAAD Surgery

Start date: April 1, 2019
Phase:
Study type: Observational

The purpose of this study was to clarify the possible mechanism of hypoxemia after surgical treatment of type A acute aortic dissection and the possible mechanism of the treatment role of inhaled nitric oxide in refractory hypoxemia.

NCT ID: NCT03607786 Recruiting - Hypothermia Clinical Trials

Antegrade Cerebral Perfusion and Retrograde Inferior Vena Caval Perfusion for Total Aortic Arch Replacement

CARTAR
Start date: January 1, 2019
Phase: N/A
Study type: Interventional

This study is designed as a multicenter, randomized, assessor- blinded clinical trial.The primary aim of this trial is to assess whether retrograde inferior venal caval perfusion combined selective antegrade cerebral perfusion(ACP)under mild hypothermia, compared with moderate hypothermia combined with selective ACP alone, improves the outcome for the patients undergoing total aortic arch replacement.

NCT ID: NCT03369977 Active, not recruiting - Clinical trials for Type A Aortic Dissection

BioGlue as an Adjunct for Structural Repair and Hemostasis in Chinese Acute Type A Aortic Dissections Patients

CHINA
Start date: November 1, 2017
Phase: N/A
Study type: Interventional

A multi-center, randomized, controlled clinical trial is designed to investigate the safety and efficacy of BioGlue as an adjunct for structural repair and hemostasis to traditional surgical repair in Chinese subject with Acute type A aortic dissections.

NCT ID: NCT02164201 Completed - Clinical trials for Thoracic Aortic Aneurysm

Post Market Surveillance Study Evaluating BioFoam Surgical Matrix in Cardiovascular Surgery

Start date: August 2014
Phase: N/A
Study type: Observational

This is a prospective, multicenter, single-arm study designed to collect clinical data to support the safety and effectiveness of BioFoam used as a surgical adjunct to anastomotic hemostasis following cardiovascular surgery. The overall objective of this clinical study is to collect clinical data supporting the safety and effectiveness of BioFoam used as a surgical adjunct to anastomotic hemostasis following cardiovascular surgery. This study is intended as a post-market surveillance (follow-up) study.