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Type 2 Diabetes clinical trials

View clinical trials related to Type 2 Diabetes.

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NCT ID: NCT02422446 Terminated - Clinical trials for Coronary Artery Disease

Effects of Eicosapentaenoic Acid on Endothelial Function in Diabetic Subjects

Start date: April 2015
Phase: Phase 3
Study type: Interventional

This pilot trial seeks to obtain preliminary data on the effects of eicosapentaenoic acid (EPA) (4g/d) on endothelial function measured via endopat2000 after 12 weeks of intervention among adults with elevated triglycerides and type 2 diabetes.

NCT ID: NCT02324491 Terminated - Obesity Clinical Trials

An Efficacy and Safety Study of Beloranib in Obese Subjects With Type 2 Diabetes Mellitus

Start date: December 2014
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate efficacy and safety of ZGN-440 (beloranib) in obese adult subjects with type 2 diabetes mellitus.

NCT ID: NCT02244164 Terminated - Type 2 Diabetes Clinical Trials

Pathophysiological Study of the Increase in Pancreatic Volume in Type 2 Diabetes Treatments.

Start date: October 2014
Phase: N/A
Study type: Interventional

Incretinomimetics and inhibitors of dipeptidyl peptidase-4 (DPP-4) are new treatments for diabetes. Previous retrospective studies have shown that these treatments induced an increase in pancreatic mass with potentially a risk for pancreatitis and development of precancerous lesions. The aim of our study is to provide a better understanding of the pathophysiological mechanisms of increased volume and / or pancreatic exocrine secretion when exposed to certain treatment of type 2 diabetes.

NCT ID: NCT02064023 Terminated - Type 2 Diabetes Clinical Trials

Comparison of Insulin Pump and MDI for Pregestational Diabetes During Pregnancy

Start date: April 2014
Phase: N/A
Study type: Interventional

This study is investigating whether insulin treatment with the insulin pump or with multiple daily injections (MDI) gives better outcomes for mother and baby in pregnant women with pregestational diabetes. Participants will be randomized to use either the insulin pump or MDI.

NCT ID: NCT02048904 Terminated - Type 2 Diabetes Clinical Trials

Use of Sitagliptin to Decrease Microalbuminuria

Start date: January 2014
Phase: Phase 4
Study type: Interventional

The people being asked to participate in this study have type 2 diabetes and abnormal levels of protein in their urine. This indicates that they are starting to develop diabetic kidney disease. The standard treatment for this is the use of one of two blood pressure medicines, either an ACE inhibitor or ARB. However, these medicines are not always completely effective in stopping/reversing the kidney disease. Some studies have previously suggested that another type of medicine, called sitagliptin, normal used to treat diabetes may also help prevent diabetic kidney disease from getting worse. This study is being performed to test the effectiveness of sitagliptin as compared to a placebo, along with a stable dose of an ACE inhibitor or ARB, to determine whether or not it will reduce protein levels in their urine. Protein levels in the urine are a marker of the severity of kidney disease.

NCT ID: NCT01944618 Terminated - Type 2 Diabetes Clinical Trials

forREAL: FORXIGA PRESCRIPTION EVENT MONITORING PROGRAM (PEMP)

forREAL
Start date: October 2013
Phase: N/A
Study type: Observational

The study purpose is to assess adverse events in patients with Type 2 diabetes who have newly been prescribed Forxiga for the management of glycemic control

NCT ID: NCT01901055 Terminated - Type 2 Diabetes Clinical Trials

Diabetes-Obstructive Sleep Apnea Treatment Trial

DOTT
Start date: February 13, 2014
Phase: N/A
Study type: Interventional

Diabetes self-management is important to help adults with type 2 diabetes achieve glucose control. Obstructive sleep apnea often co-exists with type 2 diabetes and may act as a barrier to diabetes self-management and glucose control. We will examine if treatment of obstructive sleep apnea with continuous positive airway pressure (CPAP), combined with diabetes education, results in improved diabetes self-management and glucose control.

NCT ID: NCT01788930 Terminated - Type 2 Diabetes Clinical Trials

Aspirin Resistance and Sleep Apnea in Type-2 Diabetic Patients

AREAS
Start date: February 2013
Phase: N/A
Study type: Interventional

Type-2 Diabetes and Sleep Apnea Syndrome (SAS) are both related to an increase in platelet activation. Type 2 diabetes is often associated with sleep apnea syndrome with a prevalence up to 60%. The main objective of our study is to analyze the influence of sleep apnea on the response to antiplatelet therapy in stable aspirin-treated type-2 diabetes patients. Consecutive stable aspirin-treated type-2 diabetes patients referred for suspicion of sleep apnea will be recruited after providing informed consent. Response to aspirin will be assessed with the Verify Now Aspirin(TM)rapid analyser in the morning after nocturnal polysomnography, and compared with a group of type-2 diabetes free of sleep apnea. Other endocrine, metabolic, hematologic and cardiovascular confounders will also be assessed at baseline to determine their influence on the response to aspirin. Then, Patients with severe SAS (Apnea-Hypopnea Index> 30 events/h) and response with Aspirin (ARU > 454) will be randomized to 3 months of active or sham continuous positive airway pressure treatment in a pilot study. After the 3-months of intervention, response to aspirin will be compared between the sham and effective CPAP groups.

NCT ID: NCT01787214 Terminated - Type-2 Diabetes Clinical Trials

Walnuts and Glucose Variability

Start date: June 2013
Phase: N/A
Study type: Interventional

Persons with type 2 diabetes mellitus (T2DM) have swings in their blood sugar levels that may lead to a higher risk of developing heart disease. An important part of diabetes management involves eating a diet to prevent large swings in blood sugar levels. Walnuts contain fat, protein and fiber that may reduce the swings in blood sugar. The purpose of this study is to compare the effects of a walnut-free American Diabetes Association (ADA) diet versus 2 levels of walnut-enriched ADA diets on blood sugar swings. Eighteen male and female adults with T2DM will participate in the study. Subjects will be randomized to consume an ADA diet with or without walnuts for 3 consecutive days every other week. Subjects must test their blood sugar twice daily and wear a continuous glucose monitor during the three 72-hour study periods. Subjects will be between 40 and 70 years of age and will be recruited from the surrounding community using flyers and public service announcements. Consent will take place in the Department of Nutrition at Loma Linda University by the study investigators. In total, subject participation will last 5 weeks and all meals will be provided during the 3 study periods.

NCT ID: NCT01785771 Terminated - Type 2 Diabetes Clinical Trials

A Study to Evaluate ITCA 650 for the Treatment of Type 2 Diabetes in Patients With High Baseline HbA1c

Start date: May 2013
Phase: Phase 3
Study type: Interventional

An 39-week plus extensions, open-label study to estimate the reduction in HbA1c in patients with initial HbA1c >10% </=12% who are treated with ITCA 650 20 mcg/day for 13 weeks followed by ITCA 650 60 mcg/day for 26 weeks plus optional 26-week extensions with continued treatment with ITCA 650 60 mcg/day