Type 2 Diabetes Mellitus Clinical Trial
Official title:
Effect of Yakult Ingestion on Diet-induced Insulin Resistance in Humans. A Large-cohort, Mechanistic Follow-up Study.
Participants will be randomly allocated to either Yakult ingestion or a control group. For
the first 20 days, subjects will consume their normal diet (keeping a detailed food diary
throughout). On days 21-28 they will switch to a high-fat/high-calorie diet.
The investigators hypothesise that consuming a high-fat, high-energy diet for 7 days will
alter the composition of the gut microbiota and induce metabolic endotoxaemia / systemic
inflammation as well as decreasing whole body insulin sensitivity (as we have shown
previously). In contrast, the investigators hypothesise that consuming Yakult for 21 days
before and 7 days throughout the high-fat diet will maintain a favourable gut microbiota and
prevent metabolic endotoxaemia / systemic inflammation and thus maintain insulin action /
insulin sensitivity.
n/a
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