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Tumor Recurrence clinical trials

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NCT ID: NCT06022029 Recruiting - Bladder Cancer Clinical Trials

A Dose Escalation and Dose Expansion Study of Intratumoral ONM-501 Alone and in Combination With Cemiplimab in Patients With Advanced Solid Tumors and Lymphomas.

ON-5001
Start date: October 13, 2023
Phase: Phase 1
Study type: Interventional

A phase 1, multicenter, open label, non-randomized dose escalation and dose expansion study to examine the maximum tolerated dose, (MTD), minimum effective dose (MED) and/or recommended dose for expansion (RDE) of intratumoral ONM-501 as monotherapy and in combination with a PD-1 checkpoint inhibitor in patients with advanced solid tumors and lymphomas.

NCT ID: NCT05876052 Not yet recruiting - Clinical trials for Hepatocellular Carcinoma

HOPE to Reduce Tumour Recurrence After LT In Patients With HCC

POTERE
Start date: May 2023
Phase: N/A
Study type: Interventional

Hypothermic oxygenated ex-situ machine perfusion (HOPE) is a dynamic preservation method that has been developed to reduce the incidence and severity of ischaemia-reperfusion injury and to improve outcomes after liver transplantation. Whit this study Pi and collaborators hypothesize that the application of ex-situ liver perfusion before LT in HCC recipients leads to an optimization of graft function, with a decrease in ischaemia-reperfusion injury and a possible decrease in tumor cell growth. This is multicentre, prospective, two-arm, randomized, controlled, clinical trial, that will will involve patients with HCC candidate to LT. The liver grafts will be randomized in two groups to compare HOPE and static cold storage (SCS) preservation before transplantation. For each group evaluation of clinical outcomes, graft function tests, histologic findings, perfusate, tumor characteristics, and recurrence will be done.

NCT ID: NCT05704231 Not yet recruiting - Self Efficacy Clinical Trials

The Effect of Telephone-Assisted Smoking Cessation Program in Patients Diagnosed With Non-Muscle Invasive Bladder Cancer

Start date: February 1, 2023
Phase: N/A
Study type: Interventional

This study will be carried out to examine the effect of telephone-assisted smoking cessation program on self-efficacy, smoking behavior, tumor recurrence and progression in patients with non-muscle invasive bladder cancer.

NCT ID: NCT05457595 Recruiting - Tumor Recurrence Clinical Trials

Clinical Study on the Re-irradiation of Lateral Pelvic Recurrences of Gynecological Malignancies

CYCLOPS
Start date: February 24, 2021
Phase: N/A
Study type: Interventional

The study aims to obtain a local control rate in patients with lateral pelvic relapses of gynecologycal cancers previously irradiated. High LET (Linear Energy Transfer) particles as carbon ions can guarantee a biologic advantage compared to photons in radioresistant neoplasms, given to their higher biological efficacy (RBE).

NCT ID: NCT05084586 Recruiting - Bladder Cancer Clinical Trials

Comparison of the Efficacy and Safety of Continuous and Single-Dose Intravesical Epirubicin Instillation

Start date: October 1, 2019
Phase: N/A
Study type: Interventional

In this study, the local and systemic side effects, tumor recurrens and progression rates of single or continuous epirubicin instillation during the early postoperative period were investigated in low and intermediate risk non-muscle-invasive bladder cancer.

NCT ID: NCT03515369 Not yet recruiting - Clinical trials for Hepatocellular Carcinoma

Effect of Babaodan on Tumor Recurrence After Curative Resection of Hepatocellular Carcinoma

Start date: May 2018
Phase: Phase 4
Study type: Interventional

The aim of this study is to evaluate the effect of traditional Chinese medicine Babaodan on tumor recurrence of hepatocellular carcinoma after curative resection, as well as the safety of this treatment

NCT ID: NCT03383094 Recruiting - Cancer Clinical Trials

Chemoradiation vs Immunotherapy and Radiation for Head and Neck Cancer

Start date: March 15, 2018
Phase: Phase 2
Study type: Interventional

The purpose of this study is to compare any good or bad effects of using pembrolizumab (an experimental drug) and radiation therapy (RT), compared to using cisplatin chemotherapy and radiation therapy (RT) in the treatment of patients with head and neck squamous cell carcinoma (HNSCC).