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Tonsillitis clinical trials

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NCT ID: NCT06184477 Completed - Sleep Apnea Clinical Trials

The Relationship Between Prolonged Hospitalization and Surgical Experience in Pediatric Tonsillectomy Cases.

Start date: December 1, 2023
Phase:
Study type: Observational

Guided by the expertise of a seasoned surgeon at the tertiary care hospital, the training program includes performing tonsillectomy starting from the 6th month. The clinical protocol at the hospital dictates a standard one-night hospital stay for all patients, but there is potential to extend the duration in specific cases. The study endeavors to explore the correlation between extended hospitalization, surgical proficiency, patient-specific factors, and postoperative complications in pediatric patients who underwent tonsillectomy and/or adenotonsillectomy at the clinic.

NCT ID: NCT05532228 Completed - Infections Clinical Trials

Evaluation of the Functional Impact of Adenotonsilectomy

Start date: August 20, 2020
Phase:
Study type: Observational

Spirometric assessment of respiratory function before and after adenotonsillectomy surgery

NCT ID: NCT05244226 Completed - Clinical trials for Obstructive Sleep Apnea

Pediatric Pain Optimization After Tonsillectomy

Start date: April 8, 2022
Phase: Phase 2
Study type: Interventional

The purpose of this study is to compare the use of short acting opioids (fentanyl/hydromorphone) with long acting opioids (methadone) for pain control following tonsillectomy surgery.

NCT ID: NCT04657549 Completed - Tonsillitis Chronic Clinical Trials

Tonsil Surgery in Recurrent or Chronic Tonsillitis

Start date: December 8, 2020
Phase: N/A
Study type: Interventional

Tonsil surgery is common in adults with recurrent or chronic tonsillitis. The surgical techniques include either partial or total surgical removal of the palatal tonsils (tonsillotomy, TT, and tonsillectomy, TE, respectively). The aim of this study is to find out, whether tonsil surgery improves the quality of life in these patients and whether the lighter TT is as effective as TE. Our main outcome is the disease-specific Tonsillectomy Outcome Inventory-14 (TOI-14) quality of life questionnaire score at 6 months follow-up.

NCT ID: NCT04653376 Completed - Clinical trials for Immune System Diseases

Relationship of Endoplasmic Reticulum Stress and Tonsillar Tissue Diseases

Start date: November 1, 2018
Phase:
Study type: Observational

Tonsillar tissue is a significant organ for the performing of immune systems in children. The Endoplasmic Reticulum (ER), is an organelle needed for the care of a stable function of the cells. The purpose of the study was to explore the correlation among ER stress and tonsillar tissue disorders and to explain the structure of diseases related to the immune system.

NCT ID: NCT04551196 Completed - Pain, Postoperative Clinical Trials

Management of Post-Tonsillectomy Pain in Pediatric Patients

Start date: September 28, 2020
Phase: Phase 3
Study type: Interventional

Single-center, randomized, open-label, non-inferiority treatment pilot study to evaluate the effectiveness of a combined acetaminophen and ibuprofen regimen for treatment of post-operative tonsillectomy pain in the pediatric population. 100 children undergoing tonsillectomy will be randomized to receive either a combined acetaminophen and ibuprofen regimen dosed every 6 hours or an alternating regimen of acetaminophen and ibuprofen dosed every 3 hours.

NCT ID: NCT04537819 Completed - Acute Tonsillitis Clinical Trials

Study of Imupret Application in the Technology of Delayed Prescription of Antibiotics in Patients With Acute Tonsillitis

Start date: March 20, 2019
Phase: N/A
Study type: Interventional

The problem of acute tonsillitis (AT) is one of the most urgent in modern clinical medicine. The prevalence of pathology ranges from 2 to 15% of the total population. AT (ICD J03.0-J03.9) in most cases is due to viral infections. Bacterial acute tonsillitis occurs in immunocompetent children in 20-30% of cases. To determine the indications for antibacterial therapy, the Mclsaac scale is a commonly used tool for decision. This scale is used to classify patients according to their symptoms and to determine the patients for whom antibiotic therapy is not indicated. Thus, in most cases of acute tonsillitis (even if there are 4-5 points according to the scale), it has to be taken into account that there is a low probability of the presence of GABS. Therefore, there are no unconditional indications for the prescription of antibiotics. Unjustified antibiotic therapy of AT plays a significant role in the formation of antibiotic resistance. To prevent unjustified prescription of antibiotics, a therapeutic concept of delayed administration is proposed. A patient with AT is prescribed treatment with antibiotics in a delayed manner. In the absence of a positive effect within 36-48 hours from the beginning of treatment with Imupret, the antibacterial therapy is started. The advantage of deferred antibiotic prescription is, that a higher number of patients and doctors, awaiting antibiotic therapy, may be more agreeable with this way of treatment than with a complete rejection of the antibiotic's prescription. So delayed use of antibiotics is an important treatment strategy to reduce the number of unreasonable prescriptions of antibiotics. Considering this fact, it becomes necessary to use drugs with a complex effect and evidence-based efficacy base for acute tonsillitis. At the moment, there is an insignificant evidence base for the application of the phytoneering drug Imupret in acute tonsillitis. The spectrum of its pharmacological properties includes antiviral, antibacterial, anti-inflammatory, and immunomodulating effects. The combination of these properties makes it possible to influence practically all parts of acute tonsillitis. The already existing studies were not conducted under GCP conditions. Confirmation of the high effectiveness of Imupret in the treatment of acute tonsillitis would serve as a rationale for optimizing the treatment regimen of this nosology and recommendations for the inclusion of the drug in national guidelines.

NCT ID: NCT04277299 Completed - Surgery Clinical Trials

Intelligent Customer-driven Solution for Children and Their Parents Undergoing Day Surgery

Start date: August 12, 2020
Phase: N/A
Study type: Interventional

This research aims to evaluate the effectiveness of web-based mobile intervention (Icory -Solution) developed to pediatric patients and their parents in the pathway of outpatient surgery treatment in pre-intra- and postoperative setting: (1) Examine the effectiveness of the intervention on children's preoperative anxiety and fear, and postoperative pain (2) examine the effectiveness of the intervention on parental anxiety and satisfaction in children´s care path and (3) examine the experiences of the gamification in children in the intervention group.

NCT ID: NCT04230681 Completed - Clinical trials for Obstructive Sleep Apnea

Hydromorphone vs Fentanyl in Children Undergoing Tonsillectomy Surgery

Start date: February 26, 2020
Phase: Early Phase 1
Study type: Interventional

A RCT to compare hydromorphone versus fentanyl for pain control following tonsillectomy or adenotonsillectomy surgery.

NCT ID: NCT04215770 Completed - Clinical trials for Tonsillitis Streptococcal

Comparison of Intravenous Co-amoxiclav Versus Benzyl Penicillin

Start date: January 1, 2018
Phase: N/A
Study type: Interventional

To compare intravenous Co-amoxiclav versus Benzyl penicillin in children with severe streptococcal tonsillitis in terms of efficacy, safety and cost effectiveness.