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Testing the Effect of ENDS Flavors on Neurotransmission — TEN  

Tobacco Dependence Clinical Trial

Official title:
Testing the Effect of ENDS Flavors on Neurotransmission

Clinical Trial Summary

The overarching goal of this translational proposal is to determine if neuroactive flavor chemicals can enhance the addiction potential of electronic nicotine delivery systems (ENDS) by altering brain function and behavior.

Clinical Trial Description

For this randomized double-blind controlled trial, tobacco users will be randomized to use ENDS with an e-liquid containing a neuroactive green-apple flavor (hexyl acetate) vs. an inactive green-apple flavor (ethyl acetate) for ten days as a supplement to their typical tobacco use. Laboratory measures of ENDS reinforcement, subjective ENDS ratings, and brain reactivity to the flavor using functional magnetic resonance imaging (fMRI) will be collected at baseline and after ten days of ENDS use. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05836051
Study type Interventional
Source Milton S. Hershey Medical Center
Contact Andrea Hobkirk, PhD
Phone 717-531-0003
Email ahobkirk@pennstatehealth.psu.edu
Status Recruiting
Phase N/A
Start date June 1, 2023
Completion date December 31, 2024
View Details
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