Tobacco Dependence Clinical Trial
Official title:
Varenicline Effects on Cue Reactivity and Smoking Reward/Reinforcement
The purpose of this study was to find out how varenicline works to help people quit smoking. Varenicline, also known as Chantix™, is an U.S. Food and Drug Administration (FDA) approved medication that has been shown to help people quit smoking. This study was trying to evaluate whether varenicline would change the response to smoking and the desire for cigarettes when compared to an inactive placebo control. This was not a quit smoking treatment study, and participants were not asked or required to stop smoking while in this study.
We proposed the following primary hypotheses:
1. Tonic (i.e., non-cue-provoked) craving levels would be lower in participants receiving
varenicline versus placebo.
2. Cue-provoked cravings (self-report and physiological responding) would be lower in
participants receiving varenicline versus placebo. (Secondary indices of craving
include heart rate and skin conductance.)
3. The two primary indices of nicotine reward/reinforcement (mCEQ and choice index) would
be lower in participants receiving varenicline versus placebo. (Secondary indices of
nicotine reinforcement include smoking topography variables.)
A final sample of 100 non-treatment seeking daily smokers were recruited from the Tampa-St.
Petersburg-Clearwater Metropolitan Area via paid advertisements in, and press releases to,
local newspapers, as well as targeted outdoor advertising via flyers (e.g., on public
transportation).
Following the screening session, participants were randomly assigned to receive either
varenicline or placebo medication.
;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator)
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