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Tobacco Use Disorder clinical trials

View clinical trials related to Tobacco Use Disorder.

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NCT ID: NCT03635333 Not yet recruiting - Clinical trials for Nicotine Use Disorder

Effects of E-Cigarette Flavors on Adults

Start date: September 2018
Phase: Phase 1
Study type: Interventional

This study looks at the effects of flavors when administered with nicotine in e-cigarettes in younger and older adult cigarette smokers.

NCT ID: NCT03634839 Not yet recruiting - Clinical trials for Nicotine Use Disorder

Effects of E-cigarette Flavors on Youth

Start date: September 2018
Phase: Phase 1
Study type: Interventional

This study is an examination of the influence of sweet and cooling flavors on the appeal and abuse potential of nicotine-containing e-cigarettes among susceptible youth.

NCT ID: NCT03626064 Completed - Clinical trials for Tobacco Use Disorder

The PROMPT Pilot Study

Start date: June 2014
Phase: N/A
Study type: Interventional

The PROMPT Pilot Study is a feasibility mixed methods prospective cohort study following principles of community-based participatory action research. The study recruited 80 people who use drugs and followed them for 6 months while providing access to counselling, nicotine replacement therapy and peer-support in a community setting. A notable reduction in average cigarette use per day (20.5 to 9.3) and illicit substance use (18.8%) was observed at study-end. PROMPT's patient engagement model is an effective harm-reduction strategy for the growing opioid use crisis and can improve the health outcomes of marginalised at-risk populations worldwide.

NCT ID: NCT03625986 Not yet recruiting - Tobacco Dependence Clinical Trials

Does Switching to Nicotine Containing Electronic Cigarettes Reduce Health Risk Markers

Start date: October 2018
Phase: N/A
Study type: Interventional

The overall goal of this project is to understand the likely health effects of cigarette smokers switching to a Standardized Research Electronic Cigarette (SREC) and to assess the role of nicotine delivery on switching and acceptability as well as markers of health outcomes. Current smokers who meet all eligibility criteria will completely switch from their combustible (regular) cigarettes to an electronic cigarette (SREC) that either contains 15 mg/ml of nicotine or 0 mg/ml of nicotine in the liquid. The investigators' hypothesis is that attempting to switch to a SREC will result in a reduction in markers of harms to health, as compared with the baseline (smoking) measures. The investigators also hypothesize that nicotine-containing SRECs will facilitate switching from smoking more efficiently than zero nicotine SRECs and will result in a significantly greater improvement in markers of health risk, but will result in higher ratings of dependence on the SREC (as compared to the zero nicotine SREC).

NCT ID: NCT03612960 Not yet recruiting - Tobacco Dependence Clinical Trials

Measuring Neuroadaptations in Response to Very Low Nicotine Content Cigarettes

Start date: September 2018
Phase: N/A
Study type: Interventional

The overall goal of this study is to determine if switching to very low nicotine content cigarettes changes the function of brain circuitry involved in incentive salience and executive control among dependent smokers.

NCT ID: NCT03612895 Completed - Smoking, Tobacco Clinical Trials

Proactive Population Health Strategy to Offer Tobacco Dependence Treatment to Smokers

Start date: April 2016
Phase: N/A
Study type: Interventional

Health care systems are key channels for delivering tobacco cessation treatment to the smokers in a population. A population-based approach could complement office-based care and offload busy clinicians. The project will conduct population-based proactive outreach to current smokers in a health care system's primary care practices and randomize smokers who respond to the outreach to 3 groups: 2 alternative evidence-based cessation resources or to usual care. Specific Aims: Aim 1: To determine the feasibility and reach of the program Aim 2a: To determine whether the 2 intervention arms combined increase the proportion of smokers who use tobacco cessation treatment over a 6-month follow-up compared to those randomized to usual clinical care. Aim 2b: To determine whether each of the two intervention arms increases the proportion of smokers who use tobacco cessation treatment over a 6-month follow-up, compared to those receiving usual clinical care.

NCT ID: NCT03596034 Recruiting - Tobacco Use Clinical Trials

A Study to Characterize Puff Topography With Use of JUUL 5% Electronic Nicotine Delivery Systems (ENDS) in Adult Smokers

Start date: July 30, 2018
Phase: N/A
Study type: Interventional

A Study to Characterize Puff Topography with Use of a JUUL 5% Electronic Nicotine Delivery Systems (ENDS) in Adult Smokers

NCT ID: NCT03593239 Recruiting - Nicotine Dependence Clinical Trials

Comparing the Pharmacokinetics of Nicotine Salt Based ENDS in Healthy Smokers

Start date: June 29, 2018
Phase: N/A
Study type: Interventional

A Ten Sequence, Open Label, Randomized Crossover Study Comparing Nicotine Pharmacokinetics of JUUL 1.7% and JUUL 5% Nicotine Salt Based ENDS Products, in Healthy Adult Smokers.

NCT ID: NCT03580525 Not yet recruiting - Nicotine Dependence Clinical Trials

Nicotine Delivery Rate and Its Abuse Potential: Impact of Menthol

Start date: August 1, 2018
Phase: Early Phase 1
Study type: Interventional

A placebo-controlled study to enroll male and female tobacco smokers menthol (n=35) and non-menthol (n=35) who will participate in five experimental sessions. subjects will be given an IV infusion of either saline or 1 mg nicotine at rapid, moderate or slow infusion rates (nicotine at 0.24,0.096, 0.048 and 0.024, mcg per kg body weight per sec).

NCT ID: NCT03579953 Recruiting - Smoking Clinical Trials

Nicotine TMS EFT Smoking Pilot Study

Start date: May 22, 2018
Phase: Early Phase 1
Study type: Interventional

Prior and recent evidence suggests a role of medial prefrontal cortex (MPFC) in cigarette smoking. Episodic Future Thinking (EFT) has also been shown to be associated with increased delayed discounting and reduced cigarette self administration. In the present study, we will examine whether a single administration of theta-burst transcranial magnetic stimulation (tbTMS) can increase Episodic Future Thinking and delayed discounting while reducing craving for nicotine.