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TIA clinical trials

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NCT ID: NCT05975554 Recruiting - Clinical trials for Carotid Atherosclerosis

The Effect of Low-dose Interleukin-2 on the Immune Landscape of Human Atherosclerotic Plaques at Single Cell Resolution.

ELLIPSE
Start date: August 26, 2023
Phase: N/A
Study type: Interventional

The goal of this clinical trail is to compare the differences in carotid plaque Treg cells' gene signature for activation, proliferation, and suppressive function using scRNA-seq in patients treated with IL-2 compared to control.

NCT ID: NCT05730465 Recruiting - Stroke Clinical Trials

Improving Blood Pressure Control in Stroke Patients by Increasing Access to a Home Blood Pressure Monitor

Start date: May 1, 2023
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to learn whether providing teaching with a low-cost device can help to improve blood pressure, health outcomes, patient self-efficacy without exacerbating inequity between advantaged and disadvantaged patients. The main question[s] it aims to answer are: 1. Does providing a free home blood pressure cuff improve control of hypertension? 2. Does providing a free home blood pressure cuff have a greater impact on control of hypertension in disadvantaged populations? 3. Does improved control of home blood pressure decrease adverse patient outcomes? Participants will be asked to - Take their blood pressure at home and records the results - Participate in follow-up phone calls from investigators at at 3 and 6 months Researchers will compare patients provided with home blood pressure monitors to those who are provided with routine education

NCT ID: NCT05529901 Recruiting - Stroke Clinical Trials

Japan Post Marketing Surveillance of the GORE® CARDIOFORM Septal Occluder

GSO-PFO PMS
Start date: October 3, 2022
Phase:
Study type: Observational

The purpose of this post-marketing surveillance is to evaluate the effectiveness and safety of GORE® CARDIOFORM Septal Occluder under the post-marketing setting in Japan.

NCT ID: NCT05518305 Recruiting - Stroke Clinical Trials

Platelet Expression of FcγRIIa and Arterial Hemodynamics to Predict Recurrent Stroke in Intracranial Atherosclerosis

FCG
Start date: September 30, 2022
Phase:
Study type: Observational

An observational study to determine if individuals with increased platelet FcyRIIa will have a higher risk of ischemic events.

NCT ID: NCT05476991 Recruiting - Stroke Clinical Trials

Evaluation of Low Dose Colchicine and Ticagrelor in Prevention of Ischemic Stroke in Patients With Stroke Due to Atherosclerosis

RIISC-THETIS
Start date: May 17, 2023
Phase: Phase 3
Study type: Interventional

REDUCING INFLAMMATION IN ISCHEMIC STROKE WITH COLCHICINE, AND TICAGRELOR IN HIGH-RISK PATIENTS-EXTENDED TREATMENT IN ISCHEMIC STROKE.

NCT ID: NCT05476081 Recruiting - Ischemic Stroke Clinical Trials

A REAl-life Study on Short-term DAPT in Patients With Ischemic Stroke or TIA

READAPT
Start date: February 3, 2021
Phase:
Study type: Observational [Patient Registry]

The REAl-life study on short-term Dual Antiplatelet treatment in Patients with ischemic stroke or Transient ischemic attack (READAPT) is an observational, multicenter, prospective study involving Italian centers. The study aims at evaluating effectiveness and safety of short-term (21-90 days) dual antiplatelet treatment (DAPT) in secondary prevention of mild-to-moderate ischemic stroke or high-risk TIA.

NCT ID: NCT05439356 Recruiting - Ischemic Stroke Clinical Trials

Colchicine in High-risk Patients With Acute Minor-to-moderate Ischemic Stroke or Transient Ischemic Attack (CHANCE-3)

Start date: August 11, 2022
Phase: Phase 3
Study type: Interventional

This study is a multicentre, randomized, double-blind, placebo-controlled, investigator-sponsored study that aims to investigate the efficacy of colchicine in preventing recurrent stroke in the patients with acute minor-to-moderate ischemic stroke or TIA and a hsCRP level of ≥2mg/L.

NCT ID: NCT05378490 Recruiting - Stroke, Acute Clinical Trials

The Akershus Study of Ischemic Stroke and Thrombolysis -1

ASIST-1
Start date: January 1, 2012
Phase:
Study type: Observational

This observational study comprises consecutively patients with cerebrovascular diseases admitted to the Stroke Unit at Akershus University Hospital in Norway. Akershus University Hospital is the largest emergency care hospital in Norway and has a catchment area covering a population of 550.000, which is approximately 10 % of the Norwegian population and reasonably representative according to data from Statistics Norway. The hospital is public and serving both as a primary hospital and a university hospital. Due to the Norwegian, national, all-covering health-insurance, all patients enter the hospital and are considered for further in-patient care on the same conditions. The hospital has a stroke unit classified as a comprehensive stroke center according to European Stroke Organisation standards. Acute stroke management follows national and international guidelines. Overall, the ASIST-1 study will investigate management, outcome and prognosis of stroke and stroke care pathways and later follow up in primary care using several approaches combining existing clinical data from a representative population with different Norwegian health registries. Parts of the study are retrospective with prospective follow-up by health registries and parts of the study are prospective.

NCT ID: NCT05144932 Recruiting - Stroke Clinical Trials

StrokeAlarm Trial 2

Start date: January 1, 2022
Phase: N/A
Study type: Interventional

This open, multicenter, prospective, singel-arm study will evaluate usability and feasibility of a wearable stroke indication system (Stroke Alarm) in patients with recent TIA, recent minor stroke without persistent arm motor deficit, or atrial fibrillation up to 1 month.

NCT ID: NCT05134454 Recruiting - Ischemic Stroke Clinical Trials

Atrial Fibrillation Screening Post Ischemic Cerebrovascular Events

AF-SPICE
Start date: January 20, 2022
Phase: N/A
Study type: Interventional

Stroke is one of the leading causes behind death and permanent disability in adults. Atrial fibrillation (AF) is the most common clinical arrhythmia and its prevalence is steeply increasing with age. Atrial fibrillation is associated with a manifold increase in the risk for stroke. It is considered important to investigate the heart rhythm in stroke survivors without previously known AF, because detection of AF will prompt a change in antithrombotic treatment with subsequent lowering of the risk of recurrent stroke. There are so far very few studies on the prognostic impact of ECG investigations post stroke. Despite this knowledge gap, ECG investigation post stroke is given high priority in national and international guidelines. Considerable clinical resources are currently invested in these ECG investigations without knowledge of its utility. The investigators plan a nationwide, randomised, register-based study (RRCT) including patients aged at least 70 years receiving in-hospital care for stroke or TIA (Transient Ischemic Attack). Included patients will be randomised to standard investigation (1-2 days of ECG ) or extended ECG investigation (14 days of ECG performed at least twice). Patients diagnosed AF will be offered anticoagulation treatment. Long-term follow-up will be performed via swedish health care registers. The result of this trial will have major impact on the ECG screening recommendations for patients who have had stroke, a large group of patients with dismal prognosis.