Relationship Between Computed Tomography Manifestation and Histopathological Classification of Thymic Epithelial Tumors

Thymoma Clinical Trial

Official title:

Evaluate the Relationship Between Computed Tomography Manifestation and Histopathological Classification of Thymic Epithelial Tumors

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03288662
• Other study ID #: LAnh
• Status: Completed
• Phase: N/A
• First received: September 7, 2017
• Last updated: September 19, 2017
• Start date: October 1, 2013
• Est. completion date: July 31, 2017

Study information

• Verified date: September 2017
• Source: Military Hospital 103
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

the World Health Organization (WHO) has proposed a classification of histopathological thymic tumor and it significance in prognosis. Chest computed tomography (CT) is the most common method to evaluate thymic epithelial tumors before operation. Therefore, the question is to predict the histopathological type of thymic epithelial tumors before surgery based on CT-scan images , to help determine treatment strategy and prognosis. In Vietnam, there are no published literature on this issue.

Description:

1. Introduction: the World Health Organization (WHO) has proposed a classification of histopathological thymic tumor and it significance in prognosis. Chest computed tomography (CT) is the most common method to evaluate thymic epithelial tumors before operation. Therefore, the question is to predict the histopathological type of thymic epithelial tumors before surgery based on CT-scan images , to help determine treatment strategy and prognosis. In Vietnam, there are no published literature on this issue.

2. Materials and methods:

2.1. Cross-sectional descriptive study on 53 patients with diagnosed of thymoma by CT and had postoperative histopathology results as thymic epithelial tumors

2.2. Time and Place: in Departement of CTVS, Military Hospital 103, Vietnam from 10/2013 to 7/2017.

2.3. methods:

• study in chest CT scan:

• Measure the maximun diameter of the tumor

• The contour: smooth contour or irregular contour

• The shape: round, oval and plaque base on the ratio between long axis and short axis of the tumor

• Some other characteristics: Degree of enhancement, Level of drug absorbed, Calcification, Invasion the local organs and Capsular destruction.

• Histopathological study: based on the 2004 WHO classification:

• Thymoma: type A, AB, B1, B2, B3

• Thymic carcinoma

• Data processing: use software Epi Info 2000.

3. Expectation of results

• Relationship between the size and histopathological type of thymic epithelial tumors.

• Comparison of some characteristics of the tumor on preoperative chest CT scans and histopathological type of thymic epithelial tumors

Recruitment information / eligibility

• Status: Completed
• Enrollment: 2
• Est. completion date: July 31, 2017
• Est. primary completion date: July 1, 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 21 Years to 71 Years

Eligibility

Inclusion Criteria:

• All of patient have a chest CT scan pre-operation and a result of thymic epithelial tumors postoperative histopathology

Exclusion Criteria:

• Incomplete or loss the CT and postoperative histopathology

Related Conditions & MeSH terms

• Neoplasms, Glandular and Epithelial
• Thymoma
• Thymus Neoplasms

Intervention

Other:
• CT and histopathological classification
Cross-sectional descriptive study on 53 patients with diagnosed of thymoma by CT and had postoperative histopathology results as thymic epithelial tumors. Base on the characteristics in Chest CT scan in each postoperative histopathology results.

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
Military Hospital 103	Nguyen Truong Giang

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	maximun diameter of the tumor	Measure the maximun diameter of the tumor in chest CT scan	1 month