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Clinical Trial Summary

The aim of the study is to determine the efficacy of selinexor in adults with TETs determined by overall response rate (RECIST 1.1) in two parallel cohorts of patients with advanced thymomas or thymic carcinomas. The study is an international, multicenter, open label phase II trial using Simons two stage design. The study population is adults with histologically confirmed, advanced, inoperable TETs who are progressing after treatment with least one platinum containing chemotherapy regimen.

This study is comprised of 2 similar phase II tirals, one running in EU (25 patients) and one running in US (25 patients).

There are two study arms:

Arm A: Thymoma

- Stage 1: 15 patients

- Stage 2: 10 patients

Arm B: Thymic carcinoma

- Stage 1: 15 patients

- Stage 2: 10 patients


Clinical Trial Description

Not provided ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03466827
Study type Interventional
Source Rigshospitalet, Denmark
Contact Morten Mau-Soerensen, MD, PhD
Phone +45 3545 0879
Email paul.morten.mau-soerensen@regionh.dk
Status Recruiting
Phase Phase 2
Start date October 12, 2017
Completion date July 1, 2020

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