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A Study of BKM120 (Buparlisib) in Relapsed or Refractory Thymomas

Thymoma Clinical Trial

Official title:
A Phase II Study of BKM120 (Buparlisib) in Relapsed or Refractory Thymomas

Clinical Trial Summary

Thymic tumors are rare tumors, but represent the most common tumors of the anterior mediastinum. Thymoma has an indolent course in advanced disease and has the propensity to spread to the pleura. In first line therapy, combination chemotherapy produces responses in approximately 80% of patients. A number of single agents have activity in recurrent disease, but none are curable. Patients with recurrent thymoma have limited treatment options, and thus novel target modalities are needed. At the Indiana University Simon Cancer Center (IUSCC), more patients with advance thymoma are seen than any other institution in the country. Our main hypothesis is the PI3K pathway is an important driver for growth and metastasis of thymoma and that inhibition of the PI3K pathway is expected to produce clinically meaningful response in patients with recurrent thymoma.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02220855
Study type Interventional
Source Indiana University
Contact
Status Completed
Phase Phase 2
Start date October 1, 2014
Completion date March 9, 2021
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