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Testosterone Deficiency clinical trials

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NCT ID: NCT06343870 Not yet recruiting - Menopause Clinical Trials

Estradiol and Testosterone Subdermal Implants for Menopause Treatment (ESTIME)

ESTIME
Start date: May 31, 2024
Phase: Phase 3
Study type: Interventional

Estrogen and androgen deficiencies negatively impact the quality of life of women at different stages of life, especially after menopause. New modalities and new therapeutic alternatives have been researched. Parenteral administration of estradiol and testosterone could be effective to treat symptoms secondary to estrogen and androgen deficiencies and minimize these adverse events. This study evaluates the efficiency of subdermal implant-bioabsorbable use in women with menopausal symptoms associated with secondary estrogen and androgen deficiencies in women with natural menopause, premature ovarian failure or surgical menopause due to cervical cancer. Pharmacokinetic, biochemical, metabolic, thromboembolic and hormonal data will be evaluated, as well as the effects on quality of life, menopausal symptoms and sexual function after treatment.

NCT ID: NCT06177002 Recruiting - COVID-19 Clinical Trials

SARS-CoV-2, TESTOSTERONE AND MALE FRAGILITY

PROTEGGIMI
Start date: May 19, 2020
Phase:
Study type: Observational

The hormonal environment (steroid, primarily) could have a very relevant pathophysiological role in association with SARS-CoV-2. That is, testosterone could play a relevant role in leaving male subjects more exposed to infection and more prone to developing severe complications following COVID-19 infection.

NCT ID: NCT05964920 Not yet recruiting - Healthy Aging Clinical Trials

Does Human Skeletal Muscle Possess an Epigenetic Memory of Testosterone?

Start date: January 1, 2024
Phase: Phase 2/Phase 3
Study type: Interventional

This project's primary aim of this double-blinded, randomised, placebo-controlled trial is to investigate whether short-term testosterone administration +/- resistance exercise training induces a muscle memory response that can lead to longer-lasting benefits in aged human skeletal muscle. The investigators will provide older men with the anabolic hormone, testosterone or placebo, with or without resistance training, followed by a period of testosterone abstinence and detraining, followed by a subsequent repeated period of resistance training (retraining). This will help determine if earlier encounters with short-term testosterone administration can be "remembered" and if adaptation to later retraining can be enhanced as a consequence of encountering testosterone earlier.

NCT ID: NCT05773183 Not yet recruiting - Obesity Clinical Trials

Exploring the Relationship Between Androgen Metabolism, Metabolic Disease and Skeletal Muscle Energy Balance in Men

MMetdMH
Start date: March 12, 2023
Phase:
Study type: Observational

This study relates to men with hypogonadism, a condition describing a deficiency of androgens such as testosterone. Deficiency of these hormones occurs in men due to testicular (primary) or hypothalamic-pituitary (secondary) problems or may be observed in men undergoing androgen deprivation therapy for prostate cancer. Testosterone plays an important role in male sexual development and health, but also plays a key role in metabolism and energy balance. Men with testosterone deficiency have higher rates of metabolic dysfunction. This results in conditions such as obesity, nonalcoholic fatty liver disease, diabetes, and cardiovascular disease. Studies have confirmed that treating testosterone deficiency with testosterone can reduce the risk of some of these adverse metabolic outcomes, however cardiovascular mortality remains higher than the general population. We know that testosterone deficiency therefore causes metabolic dysfunction. However, research to date has not established the precise mechanisms behind this. In men with hypogonadism there is a loss of skeletal muscle bulk and function. Skeletal muscle is the site of many critical metabolic pathways; therefore it is likely that testosterone deficiency particularly impacts metabolic function at this site. Men with testosterone deficiency also have excess fat tissue, this can result in increased conversion of circulating hormones to a type of hormone which further suppresses production of testosterone. The mechanism of metabolic dysfunction in men with hypogonadism is therefore multifactorial. The purpose of this study is to dissect the complex mechanisms linking obesity, androgens and metabolic function in men. Firstly, we will carry out a series of detailed metabolic studies in men with testosterone deficiency, compared to healthy age- and BMI-matched men. Secondly, we will perform repeat metabolic assessment of hypogonadal men 6 months after replacement of testosterone in order to understand the impact of androgen replacement on metabolism. Lastly, we will perform the same detailed metabolic assessment in men with prostate cancer before and after introduction of a drug which causes testosterone deficiency for therapeutic purposes.

NCT ID: NCT05096169 Recruiting - Clinical trials for Testosterone Deficiency

Pharmacokinetic Evaluation of Serum Testosterone Concentrations After Administration of Clomiphene Citrate

Start date: May 1, 2022
Phase: Phase 2
Study type: Interventional

This is a randomized, open-label trial examining two doses of clomiphene citrate in men with low serum testosterone concentrations (total testosterone (TT) < 300 ng/dl).

NCT ID: NCT05019859 Completed - Metabolic Syndrome Clinical Trials

Effects of a Low Carb Diet on Erectile Function and Serem Testosterone in Men With Metabolic Syndrome

Start date: October 1, 2017
Phase: N/A
Study type: Interventional

Investigate if low carb diet could increase serum testosterone level in hypogonadic men

NCT ID: NCT04983940 Completed - Clinical trials for Testosterone Deficiency

Patient Satisfaction After Switching to Oral Testosterone Undecanoate

Start date: June 18, 2021
Phase: Phase 4
Study type: Interventional

The purpose of this research study is to evaluate patient satisfaction with an oral testosterone agent, Jatenzo, compared to other forms of testosterone therapy.

NCT ID: NCT04833426 Recruiting - Prostatic Neoplasms Clinical Trials

Impact of Peri-operative tEstosterone Levels on oNcological and Functional Outcomes in RadiCal prostatEctomy

ENFORCE
Start date: December 12, 2022
Phase: Phase 3
Study type: Interventional

Sexual dysfunction is a common side effect of radical prostatectomy (RP) and has a significant negative impact on quality of life. With age the testosterone level in men declines; around 30% of men over 70 years of age meet the criteria of testosterone deficiency (TD). The negative impact of both TD and RP on sexual performance are likely to add up. The aim of this study is to assess the efficacy and safety of testosterone replacement therapy (TRT) on functional and oncological outcomes in testosterone deficient men following RP for prostate cancer (PCa).

NCT ID: NCT04717362 Withdrawn - Infertility, Male Clinical Trials

The Effects of Natesto For Treatment Of Hypogonadism

Start date: March 1, 2024
Phase: Early Phase 1
Study type: Interventional

In this prospective study, the investigators plan is to confirm the role of Natesto (intranasal testosterone) to combat hypogonadal symptoms in men trying to recover spermatogenesis following the withdrawal of conventional Testosterone replacement therapy.

NCT ID: NCT04601233 Not yet recruiting - Multiple Sclerosis Clinical Trials

Testosterone Treatment for Erectile Dysfunction and Multiple Sclerosis

Start date: June 2024
Phase: Phase 4
Study type: Interventional

The purpose of the study is to determine the effects of testosterone treatment on erectile function, fatigue, depression, cognitive function, quality of life, urinary incontinence, pain, and damage to neurons in male Multiple Sclerosis patients with low testosterone, using questionnaires, blood samples and a rectal exam in volunteers 55 years and older.