D-Serine Treatment For Tardive Dyskinesia

Status Active, not recruiting

Clinical Trial Summary

Presently no generally effective treatments for tardive dyskinesia (TD) are available. D-serine is a naturally occurring amino acid that acts in-vivo as positive allosteric modulator at the glycine site associated with the glutamatergic NMDA receptor. Previous studies have suggested that D-serine may improve motor symptoms, including dyskinesias, which are caused by treatment with presently used antipsychotics drugs.

The hypothesis under investigation in the present study is that D-serine adjuvant treatment may improve TD in schizophrenia patients diagnosed with this disorder.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Dyskinesias
Psychotic Disorders
Schizophrenia
Schizophrenia and Schizoaffective Disorder
Tardive Dyskinesia

Clinical Trial Details

NCT number	NCT01804920
Study type	Interventional
Source	Herzog Hospital
Contact
Status	Active, not recruiting
Phase	N/A
Start date	January 2013
Completion date	January 2019

View Details

See also
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Withdrawn	`NCT03254186` - Safety and Efficacy of Propranolol in the Treatment of Tardive Dyskinesia	Phase 2/Phase 3
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Terminated	`NCT00917293` - Safety and Efficacy of Pyridoxal 5' -Phosphate in the Treatment of Tardive Dyskinesia	Phase 2
Completed	`NCT01543321` - Xenazine in Late Dyskinetic Syndrome With Neuroleptics	Phase 3
Not yet recruiting	`NCT06107829` - Valbenazine Treatment of Tardive Dyskinesia in Adults With Intellectual/Developmental Disabilities	Phase 4
Completed	`NCT02405091` - Safety and Tolerability Study of NBI-98854 for the Treatment of Tardive Dyskinesia	Phase 3
Completed	`NCT03176771` - Efficacy and Safety of MT-5199 in Subjects With Tardive Dyskinesia	Phase 2/Phase 3
Terminated	`NCT02524886` - Deep Brain Stimulation for Patients With Tardive Dyskinesia and or Dystonia	N/A
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