Clinical Trials Logo
  1. Home
  2. Systemic Inflammation
  3. NCT03050476

Preventing Systemic Inflammation After Cardiac Surgery With Alkaline Phosphatase — APPIRED-III  

Systemic Inflammation Clinical Trial

Official title:
Preventing Oxidative Stress-induced Ischemic Injury- and Systemic Inflammation Complications During and After Invasive Cardiac Surgery With Alkaline Phosphatase (APPIRED III)

Clinical Trial Summary

Study should demonstrate that alkaline phosphatase reduces the incidence and extent of acute kidney injury after cardiopulmonary bypass (CPB) as defined by the AKIN criteria.

Clinical Trial Description

After cardiac surgery under cardiopulmonary bypass (CPB) patients often show impairments of the immune system. Compared to placebo, CPB patients given alkaline phosphatase will have reduced composite endpoint of acute kidney injury (AKI), late extubation, gastrointestinal or neurological complications within 7 days and AKI within 90 days. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03050476
Study type Interventional
Source Alloksys Life Sciences B.V.
Contact Ruud Brands, PhD
Phone +31 647 228 395
Email ruud@alloksys.com
Status Recruiting
Phase Phase 2/Phase 3
Start date November 1, 2017
Completion date March 31, 2026
View Details
See also
  Status Clinical Trial Phase
Completed NCT00229034 - Effect of APC and Epo on the Inflammatory Response During Sepsis N/A
Completed NCT02051634 - Papaya Study ID:20140628 Phase 1
Not yet recruiting NCT06072066 - Effects of Oral Supplement Containing L-Histidine and Antioxidants on the Skin Barrier Function and Systemic Inflammation in Rosacea N/A
Recruiting NCT04769687 - Symbiotics and Systemic Inflammation in Chronic Kidney Disease Phase 2
Completed NCT01570062 - Cardiovascular Effects of Aerosols in Residences Study Phase 2
Completed NCT01488500 - Woodsmoke Exposure and Cardiovascular Function N/A
Completed NCT01256957 - Effect of HEPA Air Filters on Subclinical Markers of Cardiovascular Health N/A
Active, not recruiting NCT03442348 - Omega 3 and Fibre Intervention Study to Improve Metabolic Health N/A
Recruiting NCT03510442 - Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still's Disease, and Related Conditions
Withdrawn NCT01092572 - Statins To Treat Adult Cystic Fibrosis Phase 1/Phase 2
Enrolling by invitation NCT06322641 - A Study to Understand the Real-world Awareness and Perceptions of Systemic inFLAMmation and rolE of hsCRP as a Biomarker in Patients With AtheroSclerotic CardioVascular Disease and Chronic Kidney Disease Among Nephrologists
Completed NCT04314739 - The Effects of Resveratrol Supplementation on Inflammation and Cognitive Performance in Healthy Adults N/A
Completed NCT04728165 - Anti-Inflammatory Effects of Time-Restricted Feeding
Completed NCT03812627 - Study of Systemic Impact of Trace Elements Release by Implantable Medical Devices. Identification of Biomarkers of Systemic Inflammation N/A
Completed NCT00780520 - The Effect of Glutamine on Systemic Inflammation During Human Experimental Endotoxemia N/A
Recruiting NCT03935061 - Effects of Mulberry Juice on Inflammatory Status and Clinical Symptoms in Patients With General Anxiety Disorder N/A
Enrolling by invitation NCT05350774 - Immunotherapy for Neurological Post-Acute Sequelae of SARS-CoV-2 Phase 2
Completed NCT00673907 - HIPWOODS - Health Effects Related to Exposure to Particle Pollution From Woodburning Stoves N/A
Completed NCT04161378 - Impact of Cardiac Rehabilitation Programs on Left Ventricular Remodeling After Acute Myocardial Infarction - the REHAB Trial
Completed NCT03448094 - The Effects of Resveratrol Supplementation on Cognition, Cerebral Blood Flow, Microbiota and Systemic Inflammation. N/A