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Preventing Systemic Inflammation After Cardiac Surgery With Alkaline Phosphatase — APPIRED-III  

Systemic Inflammation Clinical Trial

Official title:
Preventing Oxidative Stress-induced Ischemic Injury- and Systemic Inflammation Complications During and After Invasive Cardiac Surgery With Alkaline Phosphatase (APPIRED III)

Clinical Trial Summary

Study should demonstrate that alkaline phosphatase reduces the incidence and extent of acute kidney injury after cardiopulmonary bypass (CPB) as defined by the AKIN criteria.

Clinical Trial Description

After cardiac surgery under cardiopulmonary bypass (CPB) patients often show impairments of the immune system. Compared to placebo, CPB patients given alkaline phosphatase will have reduced composite endpoint of acute kidney injury (AKI), late extubation, gastrointestinal or neurological complications within 7 days and AKI within 90 days. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03050476
Study type Interventional
Source Alloksys Life Sciences B.V.
Contact Ruud Brands, PhD
Phone +31 647 228 395
Email ruud@alloksys.com
Status Recruiting
Phase Phase 2/Phase 3
Start date November 1, 2017
Completion date March 31, 2026
View Details
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