Sudden Cardiac Death Clinical Trial
Official title:
Prediction of Sudden Cardiac Death in Dilated Cardiomyopathy: The PREDICT-DCM Trial.
PREDICT-DCM Trial is a multi-centre, prospective observational trial including patients with DCM undergoing cardiac magnetic resonance imaging (CMR) prior to ICD or event recorder implantation.
Prophylactic ICD implantation was recently found to be non-beneficial over usual clinical
care in non-ischemic systolic heart failure (LVEF≤35%) and 60-70% percent of SCD cases even
occur in individuals with LEVF>35%. A growing evidence, that emphasizes the urgent need to
improve the prediction of sudden cardiac death (SCD) in dilated cardiomyopathy (DCM).
CMR provides unique information on myocardial mechanics, fibrotic burden, inflammation and
microvascular dysfunction, thereby allowing to quantify key substrates for myocardial
arrhythmogenic potential.
PREDICT-DCM Trial is a multi-centre, prospective observational trial including patients with
DCM undergoing cardiac magnetic resonance imaging (CMR) prior to ICD or event recorder
implantation.
Acquired candidate predictors are among others:
- Global and regional T1/T2
- T1/T2 inhomogeneity
- Extracellular volume fraction
- Microvascular dysfunction
- LA function and filling fraction
- Global and regional circumferential, radial or longitudinal myocardial strain
- Biomarkers
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