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NCT00000261 Clinical Trial

Effects of Alcohol History on Effects of Sevoflurane and Nitrous Oxide - 13

Substance-Related Disorders Clinical Trial

Official title:
Effects of Alcohol History on Effects of Sevoflurane and Nitrous Oxide

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00000261
Other study ID # NIDA-08391-13
Secondary ID R01DA008391R01-0
Status Completed
Phase Phase 2
First received September 20, 1999
Last updated May 26, 2015
Start date November 1997
Est. completion date October 1998

Study information
Verified date May 2015
Source University of Chicago
Contact n/a
Is FDA regulated No
Health authority United States: Federal Government
Study type Interventional

Clinical Trial Summary

The purpose of this study is to evaluate the effects of alcohol history on the subjective and reinforcing effects of sevoflurane and nitrous oxide in healthy volunteers. All subjects underwent psychomotor testing during 4 sessions of placebo, drug/placebo, and choice of intervention.

Recruitment information / eligibility
Status Completed
Enrollment 14
Est. completion date October 1998
Est. primary completion date October 1998
Accepts healthy volunteers No
Gender Both
Age group N/A and older
Eligibility Please contact site for information.

Study Design

Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Caregiver)

Related Conditions & MeSH terms

Intervention

Drug:
• 30% Nitrous oxide

Other:
• Placebo
No drug (100% oxygen)
Drug:
• 0.2% sevoflurane

• 0.4% sevoflurane

• 0.6% sevoflurane

Locations
Country Name City State
United States University of Chicago, Anesthesia & Critical Care Chicago Illinois

Sponsors (2)
Lead Sponsor Collaborator
University of Chicago National Institute on Drug Abuse (NIDA)

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Mood Baseline, inhalation, recovery No
Primary Psychomotor performance Baseline, inhalation, recovery No
Primary Choice of drug vs placebo After placebo and drug in each session
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