Gingivitis and Periodontitis as a Risk Factor for Stroke

Stroke Clinical Trial

Official title:

Gingivitis and Periodontitis as a Risk Factor for Stroke

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05101434
• Other study ID #: Gingivitis and Stroke
• Status: Completed
• Start date: January 10, 2021
• Est. completion date: July 20, 2021

Study information

• Verified date: October 2021
• Source: Shaheed Zulfiqar Ali Bhutto Medical University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

Periodontitis and gingivitis are one of the most infectious diseases in humans. Several studies have been carried out on the dependence of periodontitis and stroke. The aim of this study was to investigate gingivitis and periodontitis as risk factors for stroke in the Pakistani population.

Description:

Epidemiologic studies have shown that cerebrovascular accident (CVA) is the 3rd cause of death in developed countries with 0.8 % prevalence in the whole population. Although, the prevalence rate of stroke is reduced yet is one of the most important health problems in the United State. Periodontitis and gingivitis are the two most infectious man diseases. Today, it is estimated that about 35% of people over 30-year-old in America and 50-55% of people in developing countries are involved with these diseases.

These diseases are due to the practice of chronic bacterial infection and the inflammatory response of the host. The relationship between periodontitis and CVA was first introduced by Mackenzi and Millard in 1963 but the importance of this issue was not understood. Periodontal infection can be a complex multiphase disease by associating this infection with organ systems such as cardiovascular, endocrine, reproductive, and respiratory systems. Nowadays, periodontitis is considered a risk factor for atherosclerosis and thromboembolic disease.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 120
• Est. completion date: July 20, 2021
• Est. primary completion date: July 10, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Diagnosed stroke by using brain imaging from magnetic resonance imaging and/or computerized tomography.

Exclusion Criteria:

• Not willing to participate

• Neurological complications other than stroke

Related Conditions & MeSH terms

• Gingivitis
• Periodontitis
• Stroke

Intervention

Diagnostic Test:
• Periodontal Probing
with the help Michigan probe, periodontal pocket measurement was done.

Locations

Country	Name	City	State
Pakistan	Shaheed Zulfiqar Ali Bhutto Medical University	Islamabad	Capital

Sponsors (1)

Lead Sponsor	Collaborator
Shaheed Zulfiqar Ali Bhutto Medical University

Country where clinical trial is conducted

Pakistan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Gingivitis	Measurement of bleeding site while probing and this was done with gingival index	baseline
Primary	Periodonitis	Measurement of periodontal pockets while probing and this was done with community periodontal idex	baseline