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The Effectiveness of Oral Health Promotion on Pneumonia Complicating Stroke

Stroke Clinical Trial

Official title:
The Effectiveness of Oral Health Promotion on Pneumonia Complicating Stroke

Clinical Trial Summary

To investigate the evidence for the integration of oral health promotion as part of interdisciplinary stroke rehabilitation.

Clinical Trial Description

Pneumonia complicating stroke is very difficult to manage and has a very poor prognosis, leading to a significantly higher risk of death. Oral opportunistic pathogens have been reported to be associated with the incidence of pneumonia among non-stroke immunocompromised subjects. Preliminary studies found that patients with stroke had higher carriage rates of oral opportunistic pathogens than healthy subjects. Therefore, investigators hypothesize that pneumonia complicating stroke is associated with oral opportunistic pathogens, and oral health promotion interventions may reduce the incidence of pneumonia complicating stroke via its effects on the species and relative abundance of oral opportunistic pathogens. In order to prove this, investigators need to (1) firstly conduct a randomized controlled trial to confirm whether oral health promotion is able to reduce the levels of plaque, and the incidence of pneumonia complicating stroke at clinical level; (2) secondly employ metagenomics analysis to compare oral rinse samples and respiratory samples, and to identify pneumonia-associated "oral opportunistic pathogens group"; (3) finally elucidate how oral health promotion influences the species and relative abundance of oral opportunistic pathogens. This proposed study will provide evidence for the integration of oral health promotion as part of interdisciplinary stroke rehabilitation. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04095780
Study type Interventional
Source Anhui Medical University
Contact
Status Completed
Phase N/A
Start date November 1, 2018
Completion date June 1, 2021
View Details
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