Stroke Clinical Trial
— MINIPIC REAOfficial title:
Validation of a New Non Invasive Method for Intracranial Pressure Monitoring
Verified date | July 2014 |
Source | University Hospital, Clermont-Ferrand |
Contact | n/a |
Is FDA regulated | No |
Health authority | France: Ministry of Health |
Study type | Interventional |
In clinical practice, intracranial pressure (ICP) represents a key parameter for diagnosing
and treating several conditions. Physicians having to manage cases of head trauma, stroke
and hydrocephalus need to assess the time course of ICP, yet they are often unwilling to
implement invasive monitoring beyond the acute stage, on account of high septic risks.
Standard techniques include direct ventricular manometry or measurement in the parenchyma
with electronic or fiberoptic devices. Therefore, the design of non-invasive clinical
methods for gaining access to pressure changes is an important challenge. Fluctuations of
ICP are transmitted to the fluid spaces of the inner ear through the cochlear aqueduct. The
Biophysics Laboratory (School of Medicine of Clermont-Ferrand) described that the
intra-labyrinthic pressure modify the functional activities of the outer hair cells in the
cochlea. Thereby, increases in ICP are transferred to increases in intra-cochlear pressure,
which is detected as modifications in cochlear activities. Cochlear activities' recording
are non-invasive and technically simple. A probe is gently inserted into the outer portion
of the external ear canal.
The objective of this study is to assess prospectively the accuracy and the precision of a
new method for ICP monitoring (using cochlear activities) compared with invasive gold
standard CSF pressure monitoring.
Status | Completed |
Enrollment | 20 |
Est. completion date | November 2012 |
Est. primary completion date | November 2012 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Patients with intracranial pressure monitoring - Age greater than 18 - consent form signed by a close relative (husband, wife, children, legal guardian), - Patient covered under French social security or being a beneficiary of such a regime under the terms of the Act of August 9, 2004 Exclusion Criteria: - Refusal by the close relative to sign a consent form - Impossibility of electrophysiological measurements (pathophysiological reason) - Technical troubles with the device - Patient uncovered under French social security |
Intervention Model: Single Group Assignment, Masking: Single Blind (Subject)
Country | Name | City | State |
---|---|---|---|
France | Chu Clermont Ferrand | Clermont-Ferrand |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Clermont-Ferrand | Echodia SAS |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Cochlear Microphonic Potential phase shift | acquisition every 5minutes during 4hours | Yes | |
Secondary | IntraCranialPressure variations | every minutes during 4 hours | Yes |
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