Effect of Intensive Cognitive Rehabilitation on Cognitive, Motor, and Language Functional Networks in Subacute Stroke Patient

Stroke Clinical Trial

Official title:

Effect of Intensive Cognitive Rehabilitation on Cognitive, Motor, and Language Functional Networks in Subacute Stroke Patient

Clinical Trial Details — Status: Withdrawn

Administrative data

• NCT number: NCT05254964
• Other study ID #: 2021-12-019
• Status: Withdrawn
• Phase: N/A
• Start date: February 1, 2022
• Est. completion date: February 28, 2023

Study information

• Verified date: March 2023
• Source: Samsung Medical Center
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Altered brain networks, including cognitive, motor, and language networks, are investigated by intensive cognitive rehabilitation in subacute stroke patients.

Recruitment information / eligibility

• Status: Withdrawn
• Enrollment: 0
• Est. completion date: February 28, 2023
• Est. primary completion date: February 28, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 19 Years to 80 Years

Eligibility

Inclusion Criteria:

• Patients aged 19 to 80 years
• Patients with subacute stroke within 2 weeks of onset
• First-ever stroke
• Supratentorial stroke
• Less than 8 SAFE (shoulder abduction, finger extension) points
• Less than 35 FMA Upper scores
• MEP (motor evoked potential) negative
• Not more than 24 K-MMSE (Korean Mini-Mental State Examination) score

Exclusion Criteria:

• Difficult to communicate due to severe language impairment.
• Accompanied by an existing serious neurogenic disease
• Existing significant psychiatric disorders such as major schizophrenia, bipolar disorder
• If there are difficulties in conducting the research
• Any patients who are judged by the investigator to be difficult to participate in this study
• Patients with contraindicated MRI scans

Related Conditions & MeSH terms

• Stroke

Intervention

Procedure:
• Cognitive rehabilitation
Intensive cognitive rehabilitation by cognitive therapist for 1 hour on every working 20 days (4 weeks) during the subacute stroke phase

Locations

Country	Name	City	State
Korea, Republic of	Samsung Medical Center	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Samsung Medical Center

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Strength of connectivity in brain network obtained from MRI neuroimaging data	Participants' MRI neuroimaging data are acquired at pre- and post-intervention. Brain network can be constructed using MRI neuroimaging data, and strength of connectivity can be calculated in the brain network. Strength of connectivity has a value between -1 and 1.	Change in strength of connectivity after intensive cognitive rehabilitation for 4 weeks