Stroke Clinical Trial
— HBSOfficial title:
High B Value Diffusion and Stroke
Verified date | July 2022 |
Source | University Hospital, Bordeaux |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This study will include 100 stroke patients with significant penumbra at the acute stage and successfully recanalized thanks to thrombectomy, intravenous thrombolysis or spontaneously. Patients will be explored with the multi-b diffusion sequence on a new 3T research magnet equipped with high gradient system. In this project the investigators hypothesize that diffusion MRI at high and ultra-high b-values could be sensitive enough to quantify selective neuronal loss in the rescued penumbra and to study its relationship with the initial hypoperfusion and its impact in terms of clinical recovery.
Status | Completed |
Enrollment | 56 |
Est. completion date | June 21, 2022 |
Est. primary completion date | June 21, 2022 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Patients older than 18 years old - Cerebral infarct or cerebral hypoperfusion with neurological symptoms within the anterior circulation - Due to occlusion or stenosis of intracranial carotid artery or its branches and/or middle cerebral artery (MCA) and/or anterior cerebral artery. - With acute MRI performed within the first 24h and showing significant penumbra defined as ratio between the volumes of critically hypoperfused tissue (defined by Tmax>6s) and the ischemic core (defined by ADC<600 × 10-6 mm2/s) of 1.8 or more, with an absolute difference of 15 mL or more and ischemic core volume of less than 70 mL. - Successful recanalization by thrombectomy (TICI 2b or 2c or 3) and/or by IV thrombolysis (if within the first 4.5h) or spontaneously. - Patient/Legally Authorized Representative has signed the Informed Consent form. Exclusion Criteria: - History of symptomatic cerebral infarct with functional deficit (pre-stroke modified Rankin Scale score =1) to measure the impact of the infarct and selective neuronal loss on long-term outcome without being biased by pre-existing deficits. - History of severe cognitive impairment (dementia) or DSMIV axis 1 psychiatric disorders that would confound the neurological evaluations. - Pregnant or breast-feeding women. - Contraindications to MRI. |
Country | Name | City | State |
---|---|---|---|
France | CHU de Bordeaux | Bordeaux |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Bordeaux |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Mean Diffusivity (MD) (in 10-9 m2/s) | Computation of Mean Diffusivity (MD) metrics (in 10-9 m2/s) including MDlow for b=1000s/mm2 and pseudo-MDhigh for maps calculated from the highest b-values within the rescued penumbra and within normal contralateral symmetric region of the brain | Up to 72 hours | |
Primary | Mean Diffusivity (MD) (in 10-9 m2/s) | Computation of Mean Diffusivity (MD) metrics (in 10-9 m2/s) including MDlow for b=1000s/mm2 and pseudo-MDhigh for maps calculated from the highest b-values within the rescued penumbra and within normal contralateral symmetric region of the brain | 3 month of follow-up. | |
Secondary | Mean Kurtosis (MK) | Average of the diffusional kurtosis along all diffusion directions | Up to 72 hours | |
Secondary | Mean Kurtosis (MK) | Average of the diffusional kurtosis along all diffusion directions | 3 month of follow-up | |
Secondary | Mean Diffusivity of the slow component (MDs) | Mean Diffusivity of the slow component (MDs) within the rescued penumbra and within normal contralateral symmetric region | Up to 72 hours | |
Secondary | Mean Diffusivity of the slow component (MDs) | Mean Diffusivity of the slow component (MDs) within the rescued penumbra and within normal contralateral symmetric region | 3 month of follow-up | |
Secondary | Magnetization Transfert Ratio | Magnetization Transfert Ratio maps (MTR=(0-Ms)/M0 x100 where M0 and Ms represent the signal intensity with the saturation prepulse off and on, respectively) within the rescued penumbra and within normal contralateral symmetric region of the brain | Up to 72 hours | |
Secondary | Magnetization Transfert Ratio | Magnetization Transfert Ratio maps (MTR=(0-Ms)/M0 x100 where M0 and Ms represent the signal intensity with the saturation prepulse off and on, respectively) within the rescued penumbra and within normal contralateral symmetric region of the brain | 3 month of follow-up |
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