Stroke Clinical Trial
Official title:
Assessing the Effect of Multi-disciplinary Lifestyle Medicine Intervention on Brain-derived Neurotrophic Factor Levels Following Stroke
This is a pilot study to determine whether a lifestyle medicine intervention following stroke may increase levels of Brain-Derived Neurotrophic Factor (BDNF).
Status | Recruiting |
Enrollment | 12 |
Est. completion date | February 28, 2019 |
Est. primary completion date | January 11, 2019 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 30 Years to 90 Years |
Eligibility |
Inclusion Criteria: - History of prior stroke (ischemic or hemorrhagic) or transient ischemic attack - Ability to ambulate at least 10 feet with minimal to moderate assistance - Ability to travel to intervention site on a weekly basis. Exclusion Criteria: - Cerebral aneurysm - Concurrent pregnancy - Serious terminal illnesses (e.g. end stage renal disease, heart failure (class IV), cirrhosis (class C), metastatic cancer) - Any injury or illness preventing participation in regular aerobic exercise - Moderate-severe dementia or cognitive decline |
Country | Name | City | State |
---|---|---|---|
United States | VA Palo Alto Health Care System | Palo Alto | California |
Lead Sponsor | Collaborator |
---|---|
VA Palo Alto Health Care System | Spaulding Rehabilitation Hospital, Stanford University |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | BDNF level - Final | Plasma BDNF protein levels, expressed in nanograms per milliliter, measured prior to any exercise upon completion of intervention. | Week 12 | |
Secondary | BDNF level - Post-exercise | Plasma BDNF protein levels, expressed in nanograms per milliliter, measured immediately following bout of aerobic exercise. | Week 6 | |
Secondary | BDNF Genotype | Genotyping of venous blood samples to determine ValVal, MetMet, and ValMet distribution. | Baseline | |
Secondary | Cardiovascular Fitness - VO2 max | Measured as VO2 max (ml/kg/min). | Week 12 | |
Secondary | Cardiovascular Fitness - METs | Measured as estimated metabolic equivalents (kcal/kg/hour). | Week 12 | |
Secondary | 6-minute Walk Test | Total distance walked 6 minutes on a flat surface. | Week 12 |
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