Stroke Clinical Trial
— MORSEOfficial title:
Markers of Recovery in StrokE Study
NCT number | NCT03666897 |
Other study ID # | 2018-016 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | October 1, 2018 |
Est. completion date | April 1, 2022 |
Verified date | February 2024 |
Source | Spectrum Health Hospitals |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Our current biological understanding of stroke recovery in humans is extremely limited and this lack of knowledge is a major challenge in reducing stroke disabilities and deficits. Evidence of neural repair in humans can be gleaned indirectly through functional outcome measures, but we propose that metabolomics may also provide a minimally invasive window into human brain repair. This study will integrate clinical imaging and molecular biomarkers as a diagnostic tool in further understanding stroke recovery mechanisms.
Status | Completed |
Enrollment | 21 |
Est. completion date | April 1, 2022 |
Est. primary completion date | April 1, 2022 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Imaging confirmed ischemic stroke within 7 days of stroke onset - Age > 18 years - NIHSS = 1 on arm item OR NIHSS = 0 on arm item but < 3/5 strength on MRC scale in distal joint (flex/ext elbow or grip/ext hand) - Pre-stroke modified Rankin Scale (mRS) < 3 Exclusion Criteria: - Active malignancy (not thought to be cured or in remission) - Anemia (HCT < 25) - Sepsis - Suspected bacterial endocarditis |
Country | Name | City | State |
---|---|---|---|
United States | Spectrum Health | Grand Rapids | Michigan |
Lead Sponsor | Collaborator |
---|---|
Spectrum Health Hospitals | Georgetown University |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Establish plasma metabolite biomarkers that mirror neuronal repair and identify structural changes following ischemic strokes | Identify differential expression of select stroke plasma biomarkers of neural repair through metabolic testing and imaging CST integrity in patients with good and poor recovery following an ischemic stroke | 2 years | |
Secondary | Change in Fugl-Meyer | The Fugl-Meyer will be used to assess motor function at the shoulder, elbow, wrist, fingers, hip, knee, and foot. The scale ranges from 0 to 66 points, measuring the impairment level of the upper extremity. Zero indicates a high level of impairment or minimum hand motor function, while 66 points indicates an increased motor function which is similar to normal upper extremity function. | Baseline, 90 days post stroke |
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