Stroke Clinical Trial
Official title:
Effects of Different Frequency rTMS on Brain Functional and Structural Alterations in Stroke Patient: Multi-modal MRI Study
In this study, the investigators aim to evaluate functional and structural improvements in
the brain of stroke patients after rTMS treatment using multi-modal MRI techniques.
Specifically, the investigators sought to determine whether rTMS treatment modulate the brain
function and structure in patients and, if so, whether different frequency of the rTMS
treatment will affect the degree of the motor recovery in patients' brain.
The patients will be randomized into three groups: Experimental group 1 (TMS group) received
low frequency rTMS; Experimental group 2 (TMS group) received high frequency rTMS; The third
group who received only physical therapy constituted the control group. All patients undergo
MRI scan one day before and after rTMS treatment.
Status | Recruiting |
Enrollment | 10 |
Est. completion date | December 31, 2020 |
Est. primary completion date | December 31, 2020 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 40 Years to 75 Years |
Eligibility |
Inclusion Criteria: 1. First-ever ischemic stroke 2. One to six months after stroke onset; 3. Mini Mental State Examination (MMSE) score > 24; 4. Brunnstrom recovery stage (BRS) for hand fingers of 3-5 5. Motor deficits of the unilateral upper limb Exclusion Criteria: Patients with hemorrhage, leukoaraiosis, epilepsy, migraine or psychiatric diseases history are excluded in this study. |
Country | Name | City | State |
---|---|---|---|
China | Hangzhou Normal University | Hangzhou | Zhejiang |
China | Affiliated Hospital of Nanjing University of Chinese Medicine | Nanjing | Jiangsu |
Lead Sponsor | Collaborator |
---|---|
Hangzhou Normal University |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Brain functional changes after rTMS treatment | Brain functional changes in patients' brain measured by fMRI | One day before and after two weeks' treatment | |
Primary | Brain morphological changes after rTMS treatment | Gray matter morphological changes in patients' brain measured by high resolution T1-weighted MRI | One day before and after two weeks' treatment | |
Primary | Brain structural changes after rTMS treatment | White matter anatomical changes in patients' brain measured by DTI | One day before and after two weeks' treatment |
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