Clinical Trials Logo
NCT number NCT03298243
Study type Interventional
Source Marquette University
Contact Leigh A Mrotek, PhD
Phone (414)288-6292
Email leigh.mrotek@marquette.edu
Status Not yet recruiting
Phase N/A
Start date September 2017
Completion date May 2020

Clinical Trial Summary

Supplementing or augmenting sensory information to those who have lost proprioception after stroke could help improve functional control of the arm. Twenty-eight subjects will be recruited to a single site to evaluate the ability of various forms of vibrotactile stimulation to improve motor function, and to determine which locations of stimulation may optimize function. Participants will be tested in performing reaching movements and stabilization movements as well as more functional tasks such as simulated drinking from a glass


Clinical Trial Description

This study has two distinct aims. In aim 1, data will be collected across four days:

Day 1: Participants complete baseline screening including a test of cognition (Montreal Cognitive Assessment), clinical tests of sensory and motor function (Fugl-Meyer Assessment, two-point discrimination, vibration sensation) and a robotic test of proprioception (Arm Movement Detection Test).

Day 2: Participants will have their more affected hand wrapped around a robot handle. They will either perform reaching-type movements or hold the handle still if it attempts to make small movements. During these tasks, participants will receive vibrotactile feedback on the other arm which will provide information about hand position and/or hand speed to guide the movements.

Day 3: Participants will perform the holding-still task from the previous day while also performing a grip task. They will be cued to lightly squeeze and then relax their grip in the more affected hand while they are holding the handle as still as possible. During this time, they will be provided vibrotactile feedback to help them maintain hand position.

Day 4: Participants will perform the same task as the previous day. In this experiment, the vibrotactile feedback will be provided to the opposite arm, opposite thigh or on the same (grasping) arm.

In aim 2, data will be collected across ten days:

Day 1: Participants complete baseline screening including a test of cognition (Montreal Cognitive Assessment), clinical tests of sensory and motor function (Fugl-Meyer, two-point discrimination, vibration sensation) and a robotic test of proprioception (Arm Movement Detection Test).

Days 2-10: Participants will use the more affected arm to reach to specific 'unseen' targets in three-dimensional space, using vibrotactile feedback to guide the movement of the arm. Once participants reach the location, they will be asked to squeeze and release the fingers. View of a computer monitor will also be used during part of the experiment to help the participants guide the hand. Participants will also be asked to perform a simulated feeding task at the beginning or end of practice on each day.


Study Design


Related Conditions & MeSH terms


See also
  Status Clinical Trial Phase
Completed NCT00391378 - Cerebral Lesions and Outcome After Cardiac Surgery (CLOCS) N/A
Completed NCT01662960 - Visual Feedback Therapy for Treating Individuals With Hemiparesis Following Stroke N/A
Recruiting NCT03281590 - Stroke and Cerebrovascular Diseases Registry N/A
Not yet recruiting NCT03287739 - Recovery of Impairments Early After Stroke N/A
Recruiting NCT03305731 - Activating Behavior for Lasting Engagement After Stroke N/A
Recruiting NCT02822144 - General Anesthesia Versus Sedation During Intra-arterial Treatment for Stroke Phase 3
Not yet recruiting NCT03294187 - Encouragement-induced Movement Therapy in Daily Life Phase 2
Recruiting NCT02513589 - Molecular Imaging of Inflammation With 18F-PBR06 to Identify Unstable Carotid Plaques in Patients With Stroke Phase 2
Recruiting NCT02577276 - Evaluation of a Tele-Rehabilitation Service Program N/A
Not yet recruiting NCT03177954 - Developing a Patient Oriented Discharge Summary for Stroke Inpatients N/A
Not yet recruiting NCT03259932 - Comparison of Fatigue and Recovery After Stroke Depending on the Usual Management With or Without Physical Training N/A
Not yet recruiting NCT03274505 - Sleep Disorders in Transient Ischemic Attack and Stroke: SOMN'AIC Study N/A
Recruiting NCT03025776 - One vs. Two Hand Use After Stroke: Role of Task Requirements N/A
Recruiting NCT02889562 - Apixaban Versus Warfarin for the Management of Post-operative Atrial Fibrillation Phase 2/Phase 3
Recruiting NCT02906956 - Music and Adherence Home Programs Post Stroke Phase 0
Recruiting NCT02916030 - Vitamin D and Stroke N/A
Recruiting NCT03080454 - The Role of Trans-spinal Direct Current Stimulation (tsDCS) in Treating Patients With Hand Spasticity After Stroke N/A
Recruiting NCT02828306 - Computer Based Algorithm for Patient Specific Implants for Cranioplasty in Patients With Skull Defects N/A
Recruiting NCT02917213 - Imaging Silent Brain Infarct And Thrombosis in Acute Myocardial Infarction N/A
Active, not recruiting NCT02753257 - Validation of Sensitivity and Specificity of a Multi-Omic Precision Diagnostic for Acute Stroke Evaluation N/A