EEG Based BCI for Upper Limb Rehabilitation in Stroke

Status Recruiting

Clinical Trial Summary

Biomedical and Engineering approaches form a key element to neurological rehabilitation of upper limbs. Brain Computer Interface (BCI) using Motor execution and Motor Imagery are known to aid motor recovery in stroke. The purpose of this study is to demonstrate that Noninvasive Sensorimotor Rhythm (SMR) based EEG based BCI using motor execution and Motor Imagery tasks can aid in rehabilitation of upper limb movements in chronic stroke.

The project aims to explore an SMR-based BCI system that can exploit the sensorimotor rhythm voluntary modulation to play a virtual game as neurofeedback using motor executory tasks and imagined hand movements by stroke patients, who suffer from upper limb disability.

Clinical Trial Description

Brain Computer Interface (BCI) using Motor execution and Motor Imagery are known to aid motor recovery in stroke. The purpose of this study is to demonstrate that Noninvasive Sensorimotor Rhythm (SMR) based EEG based BCI using motor execution and Motor Imagery tasks can aid in rehabilitation of upper limb movements in chronic stroke.

The project aims to explore an SMR-based BCI system that can exploit the sensorimotor rhythm voluntary modulation to play a virtual game as neurofeedback using motor executory tasks and imagined hand movements by stroke patients, who suffer from upper limb disability. Studies have shown that movement and motor imagery (MI) (i.e., the mental rehearsal of a movement without any activation of the muscles) induce similar EEG patterns over the motor cortex.

Movement execution, preparation and even observation are usually accompanied by a decrease in µ- and β-rhythm in the cortical area representing the involved body segment. Such a reduction is called event-related desynchronization (ERD).The increase in µ-rhythm, i.e. event-related synchronization (ERS), is observed in the regions of the brain representing body segments, which are not involved in the task.This study is a pilot study to examine the feasibility of a SMR based EEG BCI using motor task and motor imagery and involve a gaming feedback for same.

The first two days will be used for calibrating the BMI using commands in computer screen followed by further two days for testing the BMI and feedback control during gaming in computer to move the ball in the computer screen. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04188132
Study type	Interventional
Source	University of Houston
Contact	Subasree R
Phone	8326721522
Email	subasree.ramakrishnan@gmail.com
Status	Recruiting
Phase	N/A
Start date	November 5, 2019
Completion date	January 31, 2020

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT05131295` - Dapsone Use in Patients With Aneurysmal Subarachnoid Hemorrhage.	Phase 3
Completed	`NCT01955642` - Evaluation of the Biological Response to Clopidogrel in Patients With Ischemic Stroke	N/A
Completed	`NCT01915368` - Determining Optimal Post-Stroke Exercise (DOSE)	N/A
Recruiting	`NCT01541163` - Heart and Ischemic STrOke Relationship studY	N/A
Recruiting	`NCT06076122` - Salicornia for Neurovascular Health Improve	N/A
Not yet recruiting	`NCT04386525` - Omega 3 and Ischemic Stroke; Fish Oil as an Option	Phase 4
Recruiting	`NCT06270927` - A Feasibility Study for Randomization of Code Stroke Imaging Strategies
Completed	`NCT02912546` - Cerebral Perfusion Associated With Postural Changes: an ASL MR Perfusion Study	N/A
Completed	`NCT02684825` - Detection of Silent Atrial Fibrillation aFter Ischemic StrOke	N/A
Completed	`NCT05815836` - Precision Medicine in Stroke
Recruiting	`NCT01673932` - Safety and Feasibility Study of Umbilical Cord Blood Mononuclear Cells Transplant to Treat Ischemic Stroke	Phase 1
Recruiting	`NCT01556802` - Use of Minocicline in Patients With Stroke	Phase 1
Completed	`NCT02101606` - Penumbral Based Novel Thrombolytic Therapy in Acute Ischemic Stroke	Phase 2
Completed	`NCT00829361` - Stroke Telemedicine for Arizona Rural Residents Trial	N/A
Terminated	`NCT00073372` - A Study of Effectiveness and Safety of Abciximab in Patients With Acute Ischemic Stroke (AbESTT-II)	Phase 3
Recruiting	`NCT04908241` - Telerehabilitation With Aims to Improve Lower Extremity Recovery Post-Stroke (TRAIL-RCT)	N/A
Completed	`NCT01443962` - The Effect of Positive End Expiratory Pressure (PEEP) During Laparoscopic Cholecystectomy	N/A
Completed	`NCT01713491` - Pre-stroke Cognitive Status and Thrombolytic Therapy	N/A
Terminated	`NCT01059149` - Safety and Long-term Effectiveness of High Frequency Repetitive Transcranial Magnetic Stimulation of Stroke (RAICup)	Phase 2
Recruiting	`NCT06081283` - Antiseizure Medication in Seizure Networks at Early Acute Brain Injury	Phase 4

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.