Stroke, Ischemic Clinical Trial
Official title:
RESCUE: A Randomized, Blinded, Placebo-controlled, Parallel Group Design to Determine the Safety of RNS60 in Large Vessel Occlusion Stroke Patients Undergoing Endovascular Thrombectomy
A Phase II, randomized, blinded, placebo-controlled, parallel group study with patients experiencing a large vessel occlusion acute ischemic stroke who are selected for endovascular revascularization. Participants will be given a 48 h infusion of either 0.5 mL/kg/h RNS60 (up to a maximum of 60 mL/h), 1 mL/kg/h RNS60 (up to a maximum of 120 mL/h), or 1 mL/kg/h (up to a maximum of 120 mL/h) placebo (normal saline) starting within 30 minutes of consent after confirmation of candidacy for endovascular thrombectomy.
This study is a Phase II, randomized, blinded, placebo-controlled, parallel group design. Participants experiencing a large vessel occlusion acute ischemic stroke who are selected for endovascular revascularization will be given a 48 h infusion of either 0.5 mL/kg/h RNS60 (up to a maximum of 60 mL/h), 1 mL/kg/h RNS60 (up to a maximum of 120 mL/h), or 1 mL/kg/h (up to a maximum of 120 mL/h) placebo (normal saline) starting within 30 minutes of consent after confirmation of candidacy for endovascular thrombectomy and prior to arterial closure. Outcomes of the main trial will be evaluated throughout a 90 day observation period. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT03993236 -
Study on Rosuvastatin+Ezetimibe and Rosuvastatin for LDL-C Goal in Patients With Recent Ischemic Stroke
|
Phase 4 | |
| Completed |
NCT04069767 -
Innovative Physiotherapy in Stroke Rehabilitation
|
N/A | |
| Recruiting |
NCT06342206 -
The Assessment of Acute /Chronic Phase in Patients With Ischemic Cerebral Stroke Using TCM Diagnostic Tools
|
||
| Recruiting |
NCT03605381 -
MORbidity PRevalence Estimate In StrokE
|
||
| Enrolling by invitation |
NCT04956211 -
Periodontal Treatment and Ischemic Stroke
|
N/A | |
| Active, not recruiting |
NCT05098236 -
Effect of Visual Retraining on Visual Loss Following Visual Cortical Damage
|
N/A | |
| Completed |
NCT03942588 -
High-intensity Interval Training After Stroke
|
N/A | |
| Recruiting |
NCT04949334 -
Effects of Respiratory Muscle Training in Patients With Acute Ischemic Stroke
|
N/A | |
| Terminated |
NCT04095767 -
Assessing Safety and Performance of the ANA Catheter System, Combined With a Stent Retriever in Acute Ischemic Stroke
|
N/A | |
| Not yet recruiting |
NCT06352086 -
Understanding Visual Processing After Occipital Stroke
|
||
| Withdrawn |
NCT04991038 -
Clinical Investigation to Compare Safety and Efficacy of DAISE and Stent Retrievers for Thrombectomy In Acute Ischemic Stroke Patients
|
N/A | |
| Completed |
NCT01937182 -
The Efficacy of Citalopram Treatment in Acute Stroke
|
Phase 2 | |
| Completed |
NCT03649295 -
Combined Conventional Speech Therapy and Functional Electrical Stimulation in Dysphagia Following Stroke
|
N/A | |
| Recruiting |
NCT05303649 -
Effects of Neuronavigated Theta Burst Stimulation in Therapy of Post-stroke Aphasia
|
N/A | |
| Completed |
NCT04233515 -
Use of Oral Anticoagulants and Symptoms in Patients With Atrial Fibrillation in Örebro County
|
||
| Completed |
NCT05102877 -
Sensory Versus Motor Level Neuromuscular Electrical Stimulation
|
N/A | |
| Completed |
NCT04089917 -
A Study of the Use of the Q Aspiration Catheter to Remove Clot in Stroke Patients
|
||
| Completed |
NCT05221112 -
Effects of PNF Patterns Training on Trunk Balance, and Gait in Chronic Stroke Patients
|
N/A | |
| Not yet recruiting |
NCT05035953 -
Thrombolysis Combined With Edaravone Dexborneol on Hemorrhagic Transformation for Acute Ischemic Stroke
|
Phase 2 | |
| Completed |
NCT06326801 -
Resistive Diaphragmatic Breathing Exercise With Pursed Lips Breathing Exercise in Sub-acute Stroke Patients
|
N/A |