Stable Coronary Artery Disease Clinical Trial
Official title:
Revacept, a Novel Inhibitor of Platelet Adhesion in Patients With Stable Coronary Artery Disease Undergoing Elective Percutaneous Coronary Interventions: a Phase II, Multicentre, Randomised, Double-blind and Placebo-controlled Study
The main objective is to evaluate the efficacy and safety of treatment with 2 doses (80 and 160 mg) of Revacept versus placebo in patients with stable coronary artery disease undergoing PCI.
Revacept is a protein that is made up of an Fc fragment ("fragment crystallisable") fused to
the GPVI receptor (the endogenous platelet collagen receptor). Consequently, Revacept binds
to its ligand (collagen) on atherosclerotic plaques preventing circulating thrombocytes from
binding to collagen exposed by the injured plaque. All this is achieved without affecting
systemic hemostasis.
Thus, blocking of GPVI-dependent pathways by interfering with vascular collagen sites is
commonly seen as an attractive target for an anti-platelet therapy of atherosclerotic
diseases.
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