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Sick Sinus Syndrome clinical trials

View clinical trials related to Sick Sinus Syndrome.

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NCT ID: NCT04632641 Completed - Atrial Fibrillation Clinical Trials

Suture Closure AFtEr VEIN Access for Cardiac Procedures (SAFE-VEIN) Trial

SAFE-VEIN
Start date: April 23, 2021
Phase: N/A
Study type: Interventional

Primary objective: To compare the safety and efficacy of closure strategies post venous access procedures. Hypothesis: We anticipate that the use of a venous closure device will decrease the time to hemostasis (TTH), time to ambulation (TTA) and time to discharge (TTD) compared to conventional methods of closure following venous access procedure.

NCT ID: NCT03843242 Completed - Heart Failure Clinical Trials

Evaluation of Ventricular Pacing Suppression Algorithms in Dual Chamber Pacemaker

LEADER
Start date: May 30, 2019
Phase: N/A
Study type: Interventional

The recent study using IRSplus and VpS algorithm from Biotronik pacemaker showed the significant reduction in ventricular pacing to less than 3%. The purpose of this study is to evaluate the efficacy of IRSplus and VpS algorithm in reducing ventricular pacing compared with conventional DDD pacing with a fixed AV delay.

NCT ID: NCT03719040 Completed - Heart Failure Clinical Trials

Physiologic Pacing Registry

Start date: November 27, 2018
Phase:
Study type: Observational [Patient Registry]

The Physiologic Pacing Registry is a prospective, observational, multi-center registry performed to gain a broader understanding of 1) physiologic pacing implant and follow-up workflows, including pacing and sensing measurements and 2) the clinical utility in creating a 3-dimensional electro-anatomical map of cardiac structures prior to physiologic pacing device implants based on the clinical site's routine care.

NCT ID: NCT03601754 Completed - Clinical trials for Sinus Node Dysfunction

Effectiveness of Closed Loop Stimulation (CLS) With His Bundle Lead Placement

Start date: July 19, 2018
Phase: N/A
Study type: Interventional

This study is a prospective, non-randomized pilot study looking to evaluate the effectiveness of Closed Loop Stimulation (CLS) in sinus node dysfunction patients with HIS bundle placement. Patients with sinus node dysfunction who have previously received a Biotronik pacemaker with His bundle lead placement as part of routine care will be recruited for the study. A hand-grip exercise will be performed at the conclusion of bicycle exercise testing in order to assess the performance of CLS during isometric exercise. After the study exercise testing is completed, data will be collected from the pacemaker.

NCT ID: NCT03564860 Completed - Heart Failure Clinical Trials

HBP Device EGM Data Collection

Start date: July 17, 2018
Phase:
Study type: Observational

This is a single-arm, non-randomized, non-blinded study designed to collect device data in patients with permanent His bundle (HB) pacing lead and an existing Abbott permanent pacemaker, defibrillator, or cardiac resynchronization device. Prospective data collection includes surface electrocardiograms, intracardiac electrograms, and pacing parameters, recorded during a patient visit. Additional retrospective data collection includes procedural data during the HB pacing lead and device implant. Up to 200 subjects will participate in this clinical investigation. The clinical investigation will be conducted at up to 8 centers worldwide. The total duration of the clinical investigation is expected to be 1 year, including enrollment and data collection from all subjects.

NCT ID: NCT03245996 Completed - Clinical trials for Aortic Blood Pressure

The Impact of Heart Rate on Central Blood Pressure in Sick Sinus Syndrome Patients With a Permanent Cardiac Pacemaker

Start date: June 2015
Phase: Phase 4
Study type: Interventional

This study is divided into two parts: - The first part evaluates the acute effect of non-pharmacological heart rate change on central hemodynamic parameters noninvasively in sick sinus syndrome patients with a permanent cardiac pacemaker - The second part evaluates the acute effects of atenolol, nebivolol and ivabradine on central hemodynamic parameters noninvasively in sick sinus syndrome patients with a permanent cardiac pacemaker at different pacing rate levels

NCT ID: NCT02976181 Completed - Clinical trials for Sinus Node Disfunction

Brady MX a Quality Improvement Study

Start date: December 2016
Phase:
Study type: Observational [Patient Registry]

Medtronic is sponsoring a quality improvement study called Brady MX. It is hypothesized that lack of awareness of treatment and diagnostics pathways result in lower number of referrals to implanters of IPG.

NCT ID: NCT02954666 Completed - Cardiac Disease Clinical Trials

Second Study on Cardio-neuromodulation in Humans

CardNMH2
Start date: December 10, 2016
Phase: N/A
Study type: Interventional

Different approaches to cardio-neuroablation (CNA) to treat neurally mediated syncope, sinus node dysfunction, and functional atrioventricular block have been published. Investigators have developed a more limited and specific approach of CNA, called cardio-neuromodulation (CardNM). This treatment is based on a tailored vagolysis of the sinoatrial node through partial ablation of the anterior right ganglionated plexus (ARGP); it is also based on an innovative anatomic strategy. The feasibility of CardNM has already been tested in our center in a limited first study in humans (CardNMH1), with a favorable outcome for the patients involved. The results of CardNMH1 have been submitted for publication. The purpose of this second study of CardNM in humans (CardNMH2) is to collect more procedural and clinical data in well-defined patient groups.

NCT ID: NCT02809131 Completed - Syncope Clinical Trials

Perioperative Antibiotic Therapy to Prevent Cardiac Implantable Electronic Device Infections.

ENVELOPE
Start date: April 1, 2016
Phase: Phase 3
Study type: Interventional

The number of cardiac implantable electronic devices (CIEDs) implanted each year has grown rapidly over the past two decades. CIED infections, defined as infections involving the generator implant site (pocket) and/or intravascular leads, have become increasingly prevalent, with the rate of growth in infections outpacing that of CIED procedures. The odds of both short term and long term mortality are at least doubled in patients who suffer CIED infections, and long term survival is particularly poor in women. Optimal strategies to prevent CIED infections in high-risk patients are largely unproven. However, recent observational studies of an antibiotic-coated envelope implanted at the time of CIED procedure have shown that this strategy is associated with a low incidence of CIED infections. Other interventions to prevent CIED infections, including the use of antibiotic irrigant used to wash the pocket during implantation and postoperative oral antibiotics, are commonly used but not supported by rigorous controlled studies. The Specific Aim of this study is to test the hypothesis that the use of the antibacterial envelope alone is noninferior to a strategy using the antibacterial envelope and intraoperative antibacterial irrigant and postoperative oral antibiotics for the reduction of cardiac implantable device infections in patients with ≥2 risk factors for infection.

NCT ID: NCT02586480 Completed - Clinical trials for Atrioventricular Block

Evolution of the PR Interval in Patients Implanted With a Pacemaker Using the SafeR Mode

PRECISE
Start date: April 2012
Phase: N/A
Study type: Observational [Patient Registry]

Observational study on long PR interval using the SafeR mode in bradycardia patients.