The Effect of Positive End Expiratory Pressure on Central Venous Pressure Among Patients With Different Lung Compliance

Sepsis Clinical Trial

Official title:

The Effect of Positive End Expiratory Pressure on Central Venous Pressure Among Patients With Different Lung Compliance

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03341572
• Other study ID #: 2017ZDSYLL094-P01
• Status: Recruiting
• Phase: N/A
• First received: November 8, 2017
• Last updated: November 13, 2017
• Start date: November 13, 2017
• Est. completion date: December 30, 2017

Study information

• Verified date: November 2017
• Source: Southeast University, China
• Contact: chenglong liang, master
• Phone: 15261893562
• Email: 15261893562[@]163.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

To observe the effect of PEEP on CVP among patients with different respiratory compliance

Description:

30 patients with mechanical ventilation and inserted central venous line will be entered. After gathering demographic data, patients undergone 5,10 and 15cmH2O PEEPs and the respective CVPs of the mentioned points will be recorded. According to the change of CVP, the patients will be divided into high response group and low response group, then comparing the lung compliance and thorax elastic resistance differences between the two groups.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 30
• Est. completion date: December 30, 2017
• Est. primary completion date: December 30, 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

1. Patients with mechanical ventilation and inserted central venous line

Exclusion Criteria:

1. The age is less than 18 years old or more than 80 years old;

2. Pregnant and lying-in woman;

3. Patients undergoing fluid resuscitation and the speed is more than 200ml/h;

4. Patients with norepinephrine dose are greater than 15 micro per minute;

5. Patients with pericarditis?pulmonary heart disease?right heart failure?atrial fibrillation;

6. Patients with COPD(endogenous PEEP is more than 2cmH2O)?tension pneumonthorax?acute episode asthma

Related Conditions & MeSH terms

• ARDS
• Brain Injuries
• Brain Injuries, Traumatic
• Sepsis
• Traumatic Brain Injury

Intervention

Other:
• 5,10 and 15cmH2O positive end expiratory pressure
every patients undergo 5,10 and 15cmH2O positive end expiratory pressure,and observe the central venous pressure of the mentioned points

Locations

Country	Name	City	State
China	Zhongda Hospital	Nanjing	Jiangsu

Sponsors (1)

Lead Sponsor	Collaborator
Jingyuan,Xu

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	CVP	Measure the central venous pressure of the three level PEEPs of 5,10 and 15cmH2O.	half an hour