Efficacy of Light Therapy for Bipolar Depression: A Randomized Controlled Trial
The purpose of this study is to understand the efficacy of light therapy for bipolar depression.
NCT00852592 — Bipolar Disorder
Status: Completed
http://inclinicaltrials.com/bipolar-disorder/NCT00852592/
Analysis of the Central Pathways Responsible for Green Light Therapy-Induced Pain Relief in Osteoarthritis
Managing joint pain is one of the main goals for treating osteoarthritis (OA) and other musculoskeletal disorders. Alleviating chronic pain pharmacologically has several potential drawbacks including diminishing efficacy, toxicity, adverse side-effects, and patient anxiety. Non-pharmacological approaches (eg. weight loss) have also been found to be effective at controlling joint pain and can provide supplementary benefits. The development of efficacious, alternative treatments for arthritis pain which provide analgesia without adverse side-effects would be advantageous. Recently, preclinical and clinical studies have demonstrated that green ambient light using light-emitting diodes (LEDs) produced profound analgesia in animal models and chronic pain patients. Both migraineurs and fibromyalgia patients have both reported significant reductions in pain following 10 weeks of green LED exposure. It is unknown how green light reduces pain, but it is believed to be in the connections between the visual and pain control centres in the brain. Investigators will examine whether green light reduces OA knee pain by altering pain processes in the brain. To assess this, we will recruit 44 participants and randomly assign them to one of two groups: one group will receive light treatments every day for 20 weeks and the other group will not. We will ask both groups to report pain in daily pain diaries and ask both groups to have a series of 3 MRI brain scans to determine if light exposure changes how the brain processes pain.
NCT06395584 — Osteoarthritis, Knee
Status: Not yet recruiting
http://inclinicaltrials.com/osteoarthritis-knee/NCT06395584/
Validation of the Improvement in the Management of Chemo-induced Mucositis in Hematology Through the Contribution of Photobiomodulation - The PHOTO-TREAT Study
Chemo-induced mucositis is a common complication in patients treated for hematologic malignancies. They can manifest itself as a simple local irritation with erythema and inflammation but can also progress to erosions and ulcerations of the entire oral mucosa and are also responsible for an increased risk of infection in these immunocompromised patients. The only therapies currently offered are local care and intravenous analgesics. Studies in pediatric hematology show the effectiveness of prevention and low-dose laser treatment in chemo-induced mucositis, both in terms of reducing the number of mucositis developed but also in terms of reducing the grade of mucositis. This currently results in a recommendation for the use of photobiomodulation by international bodies such as ESMO (European Society for Medical Oncology).
NCT06326268 — Lymphoma
Status: Recruiting
http://inclinicaltrials.com/lymphoma/NCT06326268/
Bright Light Therapy to Treat Fatigue in End Stage Kidney Disease
The goal of this clinical trial is to test light therapy in patients with end stage kidney disease who are receiving hemodialysis. The main aim is to determine if light therapy decreases fatigue severity. Participants will receive light therapy using special glasses for one hour during the dialysis sessions for four weeks of treatment.
NCT06310161 — End Stage Renal Disease
Status: Not yet recruiting
http://inclinicaltrials.com/end-stage-renal-disease/NCT06310161/
Effect of Two Different Modes of Polarized Polychromatic Non-coherent Light Therapy on Jumper's Knee
The purposes of this study are: 1. To examine the combined effects of Yellow CPPNLT and conventional treatment on pain intensity, pain pressure threshold, functional disability, and muscle strength in athletic jumper knee. 2. To examine the combined effects of Green CPPNLT and conventional treatment on pain intensity, pain pressure threshold, functional disability, and muscle strength in athletic jumper knee. 3 3- To compare between the effects of Yellow CPPNLT and Green CPPNLT on pain intensity, pain pressure threshold, functional disability, and muscle strength in athletic jumper knee.
NCT06306664 — Jumper's Knee
Status: Active, not recruiting
http://inclinicaltrials.com/jumper-s-knee/NCT06306664/
A Phase I Study of Circadian Focused Light Therapy for Fatigue Reduction in Progressive Multiple Sclerosis (NO-FATIGUE)
The study is being done to determine if treatment with a novel form of light therapy is tolerated in patients with progressive multiple sclerosis. The goal of this trial to establish the safety profile of this light therapy while generating data on its impact on fatigue, as well as its mechanism of action. Fatigue is often a complex symptom in multiple sclerosis, without any FDA-approved direct therapy. Fatigue is traditionally treated with symptom management through a multidisciplinary team.
NCT06261528 — Progressive Multiple Sclerosis
Status: Recruiting
http://inclinicaltrials.com/progressive-multiple-sclerosis/NCT06261528/
Alleviation of Depressive Symptoms in People With Intellectual Disabilities
Many adults with intellectual disabilities (ID) have depressive symptoms, which negatively impact their quality of life. A lot of of the non-medicinal forms of treatment are not or hardly suitable for people with ID. Bright light therapy (BLT) seems to be a good option. Earlier research has shown that BLT is applicable in this group and seems promising in terms of reducing depressive symptoms, without serious side effects. In part 1 of this project we investigate the implementation of BLT at Amarant. We will take the lessons learned into part 2 of this project: the implementation of BLT at Abrona. We will evaluate this process and the outcomes.
NCT06215235 — Depressive Symptoms
Status: Not yet recruiting
http://inclinicaltrials.com/depressive-symptoms/NCT06215235/
Effect of Bioptron Light Therapy on Pregnancy Related Carpal Tunnel Syndrome
The purpose of this study is to investigate the effect of bioptron light therapy on pregnancy related carpal tunnel syndrome
NCT06209918 — Carpal Tunnel Syndrome Pregnancy
Status: Recruiting
http://inclinicaltrials.com/carpal-tunnel-syndrome-pregnancy/NCT06209918/
A Randomized Controlled Double-Blind Trial of Light Therapy for Internet Gaming Disorder
This project aims to investigate (1) the efficacy of light therapy on internet gaming disorder (IGD); (2) the underlying neural mechanisms of such efficacy
NCT06165549 — Internet Gaming Disorder
Status: Recruiting
http://inclinicaltrials.com/internet-gaming-disorder/NCT06165549/
The Safety and Efficacy of Transcranial Near-infrared Light in the Treatment of Mild-Moderate Alzheimer's Disease
The goal of this study is to explore the efficacy and safety of Near-infrared light Photobiomodulation in patients with mild-moderate Alzheimer's disease(AD). This study will employ a randomized,blind,parallel controlled approach.Qualified subjects were selected and randomized (experimental group: control group=1:1). The subjects who entered the experimental group received 30 minutes of near-infrared light therapy once a day, 6 times a week, for 16 weeks of continuous treatment; The subjects who entered the control group received 30 minutes of non near-infrared light irradiation once a day (false treatment), 6 times a week, for 16 weeks.
NCT06160908 — Alzheimer Disease
Status: Recruiting
http://inclinicaltrials.com/alzheimer-disease/NCT06160908/