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Deep rTMS Modulating Insula Synaptic Density and Smoking Behavior in Schizophrenia

Schizophrenia Clinical Trial

Official title:
Deep rTMS Modulating Insula Synaptic Density and Smoking Behavior in Schizophrenia

Clinical Trial Summary

Purpose of the study: Evaluate the effect of deep repetitive transcranial magnetic stimulation (deep rTMS; hereafter abbreviated as "dTMS") on synaptic density measured with positron emission tomography (PET) and the radiotracer [11C]UCB-J. The investigators also seek to link plasticity changes in the regions targeted by the electric field (especially, the insula) to changes in the functioning of insula circuits and behavioral cigarette usage in patients with schizophrenia (SCZ). Importance of the study: This is the first study designed to directly evaluate the mechanism of action (MOA) of dTMS for smoking disruption in patients with SCZ. Patients with SCZ are a vulnerable population in high, immediate need of new smoking therapeutics for reducing premature morbidity and mortality.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05724810
Study type Interventional
Source Stony Brook University
Contact Anissa Abi-Dargham, MD
Phone 631-638-1575
Email anissa.abi-dargham@stonybrookmedicine.edu
Status Recruiting
Phase N/A
Start date April 4, 2023
Completion date August 31, 2028
View Details
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