Schizophrenia Clinical Trial
Official title:
Positive Emotions Program for Schizophrenia (PEPS): A Randomized Controlled Study on Improving Pleasure and Motivation in Schizophrenia
This study evaluates the addition of a 8 session psychological program, called Positive Emotions Program for Schizophrenia (PEPS) to improve motivation and pleasure in adults with schizophrenia. Half of the participants will receive their usual treatment and PEPS in combination, while the other half will receive usual treatment only.
Recent literature has distinguished the negative symptoms associated with a diminished
capacity to experience (apathy, anhedonia) from those which are associated with a limited
capacity for expression (emotional blunting, alogia). The apathy-anhedonia syndrome tends to
be associated with a poorer prognosis than the symptoms related to diminished expression,
suggesting that it is the more severe facet of the psychopathology. However the efficacy of
drug-based treatments and psychological interventions on primary negative symptoms remains
limited. There is a clear clinical need for developing treatments for negative symptoms.
The Positive Emotions Programs for Schizophrenia (PEPS) teaches skills to help overcome
defeatist thinking and to increase the anticipation and maintenance of positive emotions.
PEPS involves eight one-hour group sessions, administered using visual and audio materials as
part of a PowerPoint presentation of slides projected onto a screen.
The goal of the study is to establish if PEPS is clinically effective by using a randomized,
controlled and assessor-blind trial. A combination of PEPS plus treatment as usual will be
compared to treatment as usual alone. Participants diagnosed with a schizophrenia spectrum
disorder will undergo either intervention for eight weeks. Testing will evaluate individuals'
current psychopathology and ability to savor pleasure and will be performed at the time of
inclusion, at the end of the eight-week intervention and at six month follow-up.
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