Schizophrenia Clinical Trial
Official title:
CHANGE.A Randomized Clinical Trial of Health Promoting Programme Versus Standard Treatment for Patients With Schizophrenia
Schizophrenia is a life shortening disease, not only because of suicide but also because of
increased mortality from natural causes. Recently, a large register-based study, involving
complete national data from Denmark, Sweden and Finland, showed that life expectancy for
schizophrenia is 20 years shorter for men and 15 years shorter for women, compared to the
general population, and that mortality from medical conditions and diseases are responsible
for a large proportion of the reduced life expectancy. Patients with schizophrenia had a
twofold to fivefold increased risk of death by coronary heart disease, respiratory diseases,
lung cancer and metabolic conditions. Unhealthy life style and undetected and untreated
physical disorders play an important role in this excess mortality.Results from the Danish
National Indicator Project for Schizophrenia showed that a much higher proportion of
patients with schizophrenia compared to the general population have measures of waist
circumference, body mass index, blood pressure, blood lipids and blood glucoses above the
recommended upper values.
In the randomized clinical trial CHANGE, the investigators will evaluate the effect of two
different interventions both aiming to reduce risk for death from medical diseases. We will
compare 1) treatment as usual with 2) affiliation to a care coordinator who has the duty to
connect the patient to general practice and primary care and 3) affiliation to a staff
member from the CHANGE team who should facilitate life style changes and contact with
general practice. The objective is to identify interventions that can reduce the risk of
early death in patients with schizophrenia.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Prevention
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