Schizophrenia Clinical Trial
Official title:
Biological and Behavioral Mechanisms of Smoking in Schizophrenia
Verified date | August 2020 |
Source | Brown University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The objective of this study is to investigate the relative contributions of nicotine replacement and sensorimotor replacement (i.e., smoking denicotinized cigarettes) on abstinence-induced smoking urges, withdrawal-related negative affect, psychiatric symptoms, cognitive task performance and 90-min ad libitum usual-brand smoking behavior in smokers with schizophrenia and non-psychiatric smokers.
Status | Completed |
Enrollment | 75 |
Est. completion date | March 2011 |
Est. primary completion date | March 2011 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 99 Years |
Eligibility | Inclusion Criteria: - schizophrenia or no psychiatric illness - 18 and older - men and women - cigarette smokers, 20-50 cigarettes per day - would like to quit someday Exclusion Criteria: - medical conditions excluding transdermal nicotine replacement - pregnancy or lactation |
Country | Name | City | State |
---|---|---|---|
United States | Brown University, 121 South Main Street | Providence | Rhode Island |
Lead Sponsor | Collaborator |
---|---|
Brown University | National Institute on Drug Abuse (NIDA) |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Preferred Brand Smoke Intake (CO) | preferred brand smoke intake (breath CO) after 5-hr "satiation" periods in which nicotine replacement and sensorimotor replacement were provided under double-blind conditions | 90 min | |
Secondary | Questionnaire on Smoking Urges - Brief Scale (QSU-Brief) | Measure of cigarette craving in which 10 items were rated on 100-mm visual analogue scales (0 = "no urge at all", 100 = "strongest urge you've ever had") | 5 hr |
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