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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT06226779
Other study ID # 202400006B0
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date January 16, 2024
Est. completion date February 15, 2025

Study information

Verified date January 2024
Source Chang Gung Memorial Hospital
Contact Chyi-Rong Chen, Master
Phone 886-7-7317123
Email ccr776@cgmh.org.tw
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The current study intends to recruit participants with schizophrenia for the practice of Baduanjin, brisk walking, and health education after enrollment. The study also including a maintenance program. Cognitive and physical function assessments will be conducted before, after, and during follow-up tests. The research hypothesis posits that both Baduanjin and brisk walking will confer beneficial effects on various aspects of cognitive and physical functions.


Description:

Cognitive function deficits are core features in patients with schizophrenia. These deficits need active intervention to prevent functional decline. Baduanjin and brisk walking show promise as interventions in patients with schizophrenia. This study investigated the effects of Baduanjin exercise versus brisk walking in patients with schizophrenia. This study will be a single-blind, 3-arm, parallel, randomized controlled trial. A total of 120 patients with schizophrenia will be enrolled and randomly assigned to the Baduanjin group, brisk walking group or control group. The intervention group will practice Badunjin exercise. While participants in brisk walking group will receive brisk walking at the same duration. The controls will watch videos that are not aimed at improving physical exertion. Maintenance programs will also be conducted for participants to encourage practicing in exercise after intervention. All group will undergo evaluation at three time points: baseline, immediately after intervention and 4-week follow up after intervention. The primary outcome will be cognitive function and physical function. Secondary outcomes will include mood, sleep quality, and quality of live.


Recruitment information / eligibility

Status Recruiting
Enrollment 120
Est. completion date February 15, 2025
Est. primary completion date May 15, 2024
Accepts healthy volunteers No
Gender All
Age group 20 Years to 65 Years
Eligibility Inclusion Criteria: 1. Having a diagnosis of schizophrenia according to the DSM-5. 2. Who will be above 20-65 years of age . 3. Having a stable mental status without shift in medication and keep in same dose for at least one month. 4. Being able to walk independently for 50 meters. Exclusion Criteria: 1. Serious physical conditions that will impede participation, such as cardiovascular disease, musculoskeletal disease or pulmonary system disease. 2. Visual or auditory impairment that precludes completion of assessment. 3. Acute psychosis requiring hospitalization. 4. Presence of severe withdrawal or profound cognitive disability that cause difficulties in following instructions.

Study Design


Related Conditions & MeSH terms


Intervention

Behavioral:
Baduanjin exercsie
The Baduanjin exercise consists of 8 postures, with emphasis on different body parts. The exercise is commonly practiced as follows: (1) 2 hands holding up the heavens, (2) drawing the bow to shoot the eagle, (3) separating the heaven and earth, (4) wise owl gazing backwards, (5) swaying the head and shaking the tail, (6) 2 hands holding the feet to strengthen the waist, (7) clenching the fists and glaring fiercely, and (8) bouncing on the toes.
Brisk walking
The brisk walking will be gradually increased physical exertion from light to moderate of intensity. During the training period, the heart rate of participants will be monitored.
Health education
Health education will include lecture classes. Video watching will watch videos which were not aim at improving physical exertion, such as sports games or sports related variety shows

Locations

Country Name City State
Taiwan Chang Gung Memorial Hospital, Kaohsiung Medical Center Kaohsiung

Sponsors (1)

Lead Sponsor Collaborator
Chang Gung Memorial Hospital

Country where clinical trial is conducted

Taiwan, 

Outcome

Type Measure Description Time frame Safety issue
Primary Change score of the Brief Assessment of Cognition in Schizophrenia (BACS) BACS is a battery of cognition tests that measure verbal memory, working memory, motor speed, verbal fluency, attention and processing speed, and executive function.The BACS is comprised of seven subtests: (1) the List Learning Test, (2) Digit Sequencing Test, (3) Token Motor Test, (4) Category Instance Test, (5) Controlled Oral Word Association Test, (6) Symbol Coding, and (7) Tower of London Test. Baseline, immediate after treatment, 4-week follow up
Primary Change scores of 6-minute walk test This test evaluates cardiovascular fitness and walking speed. Baseline, immediate after treatment, 4-week follow up
Primary Change scores of 30-second chair stand test This test evaluates muscular endurance of lower-extremities. Baseline, immediate after treatment, 4-week follow up
Primary Change scores of Timed up-and-go test This test evaluates functional mobility, agility and balance Baseline, immediate after treatment, 4-week follow up
Primary Change scores of dual task Timed up-and-go test (manual) This test requires carry a cup of water 3 cm from the top of the cup while performing the Timed up-and-go test. It evaluates dual task performance. Baseline, immediate after treatment, 4-week follow up
Primary Change scores of dual task Timed up-and-go test (cognitive) This test combine serial three counting and Timed up-and-go test simultaneously. It evaluates dual task performance. Baseline, immediate after treatment, 4-week follow up
Secondary Change score of Depression, Anxiety Stress Scales-21 (DASS-21) DASS-21 is a self-report questionnaire that measure symptoms of depression, anxiety, and stress. Baseline, immediate after treatment, 4-week follow up
Secondary Change score of Pittsburg Sleep Quality Index PSQI is a self-report assessment which contains 19 items to measure sleep quality Baseline, immediate after treatment, 4-week follow up
Secondary Change score of Euro-Qol 5-Dimmensions (EQ-5D). EQ-5D is a self-reporting questionnaire that measures five dimensions of health state: (1) mobility, (2) self-care, (3)usual activities, (4) pain/discomfort, and (5) anxiety/depression. Baseline, immediate after treatment, 4-week follow up
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